Observing cancer relapse and quality of life after kidney surgery
Official title: 2014 Transizionali - Observational Study on the Occurrence of Relapses and on the Quality of Life in Patients Who Underwent Nephroureterectomy Surgery
Run by IRCCS San Raffaele · NCT06169436 · Data updated 2026-11-12
This study looks at how kidney surgery affects cancer relapse and the overall quality of life for patients with a specific type of urinary tract cancer.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1250 (estimated) |
| Sponsor | IRCCS San Raffaele Academic / other |
| Locations | 1 site (Milan, MI) |
| Status | Recruiting |
| Started | July 17, 2014 |
| Main results expected | July 17, 2064 |
| Study ends | July 17, 2064 |
| Registry record updated | December 13, 2023 |
| Trial ID | NCT06169436 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older diagnosed with upper tract urothelial cancer who are indicated for nephroureterectomy surgery.
✕Probably not a fit
Patients under 18 years old or those without a diagnosis of upper tract urothelial cancer will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients who have undergone nephroureterectomy surgery for upper urinary tract urothelial carcinoma. It aims to collect both prospective and retrospective data on oncological relapse, clinical progression, and quality of life, including psychological and sexual health aspects. A dedicated database will facilitate secure data extraction for statistical analysis, enhancing the understanding of patient outcomes and informing future therapeutic strategies. The study will utilize clinical reports from patients treated since 1987 to enrich the data set.
Why it matters
Potential benefit: If successful, this study could improve patient care and treatment strategies for those with upper urinary tract urothelial carcinoma.
How similar studies have gone: Other studies have shown success in observing quality of life and relapse in cancer patients, making this approach both relevant and supported by existing literature.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years or older * Upper tract urothelial cancer diagnosis * Indication to cancer removal through nephroureterectomy surgery * Ability to read and sign the informed consent Exclusion Criteria: * Age \< 18 years * Absence of upper tract urothelial cancer * Inability to read and sign the informed consent
Where it's running
-
IRCCS Ospedale San Raffaele
Milan, Mi, Italy Recruiting
Study contacts
- Principal investigator: Francesco Montorsi, MD — IRCCS Ospedale San Raffaele
- Study coordinator: Francesco Montorsi, MD.
- Email: montorsi.francesco@hsr.it
- Phone: 02 2643 7286
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Danish Bladder Cancer Group 23: European effort on cancer in the upper urinary tract
This project will see if kidney-sparing surgery can be used safely for adults with upper urinary tract urothelial carcinoma instead of removing the entire kidney and ureter.
-
UGN-104 treatment for low-grade upper tract urothelial cancer
This Phase 3 trial tests whether weekly UGN-104 instillations can clear low-grade upper tract urothelial cancer in patients with small papillary tumors in the renal pelvis.
-
Combining DV and Toripalimab for Kidney Preservation in Patients with Urothelial Carcinoma
This study is testing a new combination treatment of DV and toripalimab to see if it can help people with kidney problems and bladder cancer keep their kidneys while treating their cancer.
-
Adjuvant disitamab vedotin plus radiotherapy for HER2‑overexpressing upper urinary tract urothelial carcinoma with high recurrence risk
This study will try whether adding disitamab vedotin to radiotherapy after surgery helps people with HER2‑positive upper urinary tract urothelial carcinoma who are at high risk of recurrence.
-
Combining RC48 and Tislelizumab for kidney preservation in high-risk UTUC patients
This study is testing a new combination of two treatments, RC48 and Tislelizumab, to see if they can help protect the kidneys in patients with high-risk upper urinary tract cancer.
-
Urinary Cell-Free DNA Test for Urothelial Cancer Origin
This study tests a urine-based cell-free DNA test to help diagnose urothelial cancer and identify whether it started in the bladder or upper urinary tract in adults.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.