A registry for adults with esophageal movement and reflux problems.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This registry enrolls adults referred to the Digestive Physiopathology division at IRCCS San Raffaele and captures clinical, endoscopic, radiologic and surgical history. Participants undergo standard-of-care physiologic testing including high-resolution manometry, 24-hour pH-impedance monitoring and FLIP, whether they are treatment-naïve or post-foregut surgery. The dataset integrates multimodal physiologic measurements with clinical outcomes to identify phenotypes of GERD, achalasia and other motility disorders and to support long-term follow-up. Analyses will focus on correlations between physiologic findings and clinical/endoscopic/radiologic data to better inform diagnostic and management pathways.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Participant is willing and able to give informed consent for participation in the study.
2. The procedures are the standard of care for the patient or the participant is taking the medicinal product according to clinical practice
3. Aged \> 18 years.
4. Any typical (heartburn or regurgitation) or atypical reflux symptom (Laryngeal Cough, laryngitis, sub-glottic stenosis, globus, laryngeal cancer, vocal cord granuloma, vocal cord irritation, vocal cord polyps and post-nasal drip; Oropharyngeal: Dental erosion, pharyngitis, sore or burning throat, gingivitis and halitosis; Ears and sinuses: Earaches, otitis media and sinusitis; Pulmonary: Chronic bronchitis, pneumonia, aspiration, bronchiectasis, asthma and idiopathic pulmonary fibrosis; Cardiac: Arrhythmia, angina and myocardial infarction; Sleep: Sleep apnoea, sleep deprivation, insomnia, snoring, nightmare and sleep disturbance), but also any obstructive esophageal symptom potentially reflecting a primary or secondary motility disorder (oropharyngeal or esophageal dysphagia, chest pain, bolus impaction). Every patient with a diagnosis of esophageal inflammatory disorder (including EoE and others) or systemic rheumatological condition (scleroderma, systemic sclerosis, lichen planus and others), every patient previously undergone to any anti-reflux surgery, bariatric surgery, endoscopic or surgical esophageal or gastric myotomy (also for gastroparesis) may be included.
5. Patients must be referred to the Digestive Physiopathology Unit of IRCCS San Raffaele Hospital for motility tests

Exclusion Criteria:

1. Age \< 18 years
2. Not willing to provide informed consent to the inclusion in the registry

Where it's running

• IRCCS San Raffaele Hospital
  Milan, Lombardy, Italy Recruiting

Study contacts

• Study coordinator: Alberto Barchi, MD
• Email: barchi.alberto@hsr.it
• Phone: +390226432643

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using a mucosal impedance device to help diagnose chronic esophageal problems

  This test tries a mucosal impedance device during upper endoscopy to see if it helps diagnose people with chronic reflux (GERD) or eosinophilic esophagitis.

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• Full-thickness vs progressive myotomy in POEM for achalasia

  This trial tests whether a full-thickness myotomy during POEM works better than a partial, progressive approach for people with achalasia, to see which method better relieves symptoms with fewer side effects.

  Recruiting at 2 sites Phase 2 Cairo University · Cairo and 1 other locations · NCT07875686

• Thread-Embedding Acupuncture plus a Proton Pump Inhibitor for GERD

  This study tests whether adding thread-embedding acupuncture to standard omeprazole treatment helps people with GERD who have a traditional Liver-Stomach constraint-heat pattern.

  Recruiting University of Science Ho Chi Minh City · Ho Chi Minh City · NCT07797959

• Impact of Patient Position on EndoFLIP Measurements in Kids and Young Adults

  This study tests whether EndoFLIP measurements differ when patients are in the supine versus left-side position during the procedure.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07780981

• Upadacitinib for Eosinophilic Esophagitis in adults not responding to standard therapy

  This study tests whether upadacitinib, taken with topical corticosteroids, can reduce disease activity in adults with eosinophilic esophagitis who still have symptoms.

  Recruiting Phase 2 University of North Carolina, Chapel Hill · Chapel Hill, North Carolina and 1 other locations · NCT07588568

• Multicenter chest X-ray screening for thoracic diseases

  This project will test whether routine chest X-rays can detect thoracic problems in adults who come for routine health examinations.

  Recruiting Chinese Academy of Sciences · Dazhou, Sichuan · NCT07585214

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.