Clinical trial Recruiting at 1 site Observational Ages 18 and up

Creating personalized 3D models of pancreatic neuroendocrine tumors

Official title: Development of New Personalised 3D Preclinical Models of Pancreatic Neuroendocrine Tumours

Run by IRCCS San Raffaele · NCT06121622 · Data updated 2026-11-12

This study is trying to create personalized 3D models of pancreatic neuroendocrine tumors from patients' surgical samples to better understand the disease and test new treatments.

More Pancreatic Neuroendocrine Tumor trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment70 (estimated)
SponsorIRCCS San Raffaele
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Milan, MI)
StatusRecruiting
StartedJanuary 16, 2024
Main results expectedNovember 2029
Study endsDecember 2029
Registry record updatedMay 1, 2025
Trial IDNCT06121622 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older who are undergoing surgical resection for non-functioning pancreatic neuroendocrine tumors.

Probably not a fit

Patients with non-pancreatic neuroendocrine tumors or those under 18 years of age may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop personalized 3D preclinical models of pancreatic neuroendocrine tumors (PanNETs) using surgical specimens from patients. The models will help researchers understand the mechanisms of disease progression and facilitate drug testing. By replicating the tumor's complex biology and microenvironment, the study seeks to address the current lack of effective preclinical models for PanNETs. The research will focus on patients undergoing surgical resection for non-functioning PanNETs, ensuring that the models are tailored to individual patient characteristics.

Why it matters

Potential benefit: If successful, this study could lead to more effective treatment strategies for patients with pancreatic neuroendocrine tumors.

How similar studies have gone: While the approach of creating personalized 3D models is innovative, similar studies have shown promise in other tumor types, indicating potential for success in this area as well.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion criteria:

* patients who undergo pancreatic surgical resection for non-functioning pancreatic neuroendocrine tumor
* age ≥ 18 years
* informed consent

Exclusion criteria:

* non-pancreatic neuroendocrine tumor histological diagnosis
* age \< 18 years

Where it's running

  • IRCCS San Raffele Institute
    Milan, Mi, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  • Using chemotherapy after surgery for high-risk pancreatic neuroendocrine tumors

    This study tests if a combination of two chemotherapy drugs can help prevent cancer from coming back in people who have had surgery for high-risk pancreatic neuroendocrine tumors.

    Recruiting at 381 sites Phase 2 SWOG Cancer Research Network · Anchorage, Alaska and 447 other locations · NCT05040360

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.