Creating personalized 3D models of pancreatic neuroendocrine tumors
Development of New Personalised 3D Preclinical Models of Pancreatic Neuroendocrine Tumours
This study is trying to create personalized 3D models of pancreatic neuroendocrine tumors from patients' surgical samples to better understand the disease and test new treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 70 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS San Raffaele Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Milan, MI) |
| Trial ID | NCT06121622 on ClinicalTrials.gov |
What this trial studies
This observational study aims to develop personalized 3D preclinical models of pancreatic neuroendocrine tumors (PanNETs) using surgical specimens from patients. The models will help researchers understand the mechanisms of disease progression and facilitate drug testing. By replicating the tumor's complex biology and microenvironment, the study seeks to address the current lack of effective preclinical models for PanNETs. The research will focus on patients undergoing surgical resection for non-functioning PanNETs, ensuring that the models are tailored to individual patient characteristics.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are undergoing surgical resection for non-functioning pancreatic neuroendocrine tumors.
Not a fit: Patients with non-pancreatic neuroendocrine tumors or those under 18 years of age may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatment strategies for patients with pancreatic neuroendocrine tumors.
How similar studies have performed: While the approach of creating personalized 3D models is innovative, similar studies have shown promise in other tumor types, indicating potential for success in this area as well.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * patients who undergo pancreatic surgical resection for non-functioning pancreatic neuroendocrine tumor * age ≥ 18 years * informed consent Exclusion criteria: * non-pancreatic neuroendocrine tumor histological diagnosis * age \< 18 years
Where this trial is running
Milan, MI
- IRCCS San Raffele Institute — Milan, Mi, Italy (Recruiting)
Study contacts
- Study coordinator: Massimo Falconi, Professor
- Email: falconi.massimo@hsr.it
- Phone: 0039 022643 6046
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.