Creating personalized 3D models of pancreatic neuroendocrine tumors
Official title: Development of New Personalised 3D Preclinical Models of Pancreatic Neuroendocrine Tumours
Run by IRCCS San Raffaele · NCT06121622 · Data updated 2026-11-12
This study is trying to create personalized 3D models of pancreatic neuroendocrine tumors from patients' surgical samples to better understand the disease and test new treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | IRCCS San Raffaele Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Milan, MI) |
| Status | Recruiting |
| Started | January 16, 2024 |
| Main results expected | November 2029 |
| Study ends | December 2029 |
| Registry record updated | May 1, 2025 |
| Trial ID | NCT06121622 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who are undergoing surgical resection for non-functioning pancreatic neuroendocrine tumors.
✕Probably not a fit
Patients with non-pancreatic neuroendocrine tumors or those under 18 years of age may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to develop personalized 3D preclinical models of pancreatic neuroendocrine tumors (PanNETs) using surgical specimens from patients. The models will help researchers understand the mechanisms of disease progression and facilitate drug testing. By replicating the tumor's complex biology and microenvironment, the study seeks to address the current lack of effective preclinical models for PanNETs. The research will focus on patients undergoing surgical resection for non-functioning PanNETs, ensuring that the models are tailored to individual patient characteristics.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatment strategies for patients with pancreatic neuroendocrine tumors.
How similar studies have gone: While the approach of creating personalized 3D models is innovative, similar studies have shown promise in other tumor types, indicating potential for success in this area as well.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * patients who undergo pancreatic surgical resection for non-functioning pancreatic neuroendocrine tumor * age ≥ 18 years * informed consent Exclusion criteria: * non-pancreatic neuroendocrine tumor histological diagnosis * age \< 18 years
Where it's running
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IRCCS San Raffele Institute
Milan, Mi, Italy Recruiting
Study contacts
- Study coordinator: Massimo Falconi, Professor
- Email: falconi.massimo@hsr.it
- Phone: 0039 022643 6046
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This project will test an AI tool that reads contrast-enhanced CT scans to help doctors decide whether people with suspected pancreatic disease need surgery, close monitoring, or routine follow-up.
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Near‑total debulking surgery versus non‑surgical management for metastatic pancreatic neuroendocrine tumours
This study will test whether removing most of the tumour (near‑total debulking surgery) helps adults with stage 4 non‑functional pancreatic neuroendocrine tumours live longer or feel better compared with not doing debulking.
-
Personalized mRNA vaccine for advanced endocrine tumors
This study is testing a personalized mRNA vaccine to see if it can help patients with advanced endocrine tumors who haven't had success with standard treatments.
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Early detection of pancreatic neuroendocrine tumors using blood tests
This study is testing a new blood test to see if it can help find pancreatic neuroendocrine tumors earlier than current methods in adults who have not yet received treatment.
-
Using chemotherapy after surgery for high-risk pancreatic neuroendocrine tumors
This study tests if a combination of two chemotherapy drugs can help prevent cancer from coming back in people who have had surgery for high-risk pancreatic neuroendocrine tumors.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.