Ultra‑high‑resolution CT to look for lung and heart damage in progressive interstitial lung disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project uses multidimensional and ultra‑high‑resolution computed tomography (CT) to capture detailed images of both the lungs and heart in adults with progressive or long‑standing interstitial lung disease. Participants undergo advanced, contrast‑enhanced CT protocols designed to quantify interstitial fibrosis and to reveal subclinical cardiac changes such as ischemic signs or right ventricular dysfunction. Imaging findings will be compared with clinical history and eligibility data to characterize patterns of cardiopulmonary damage and to explore links between lung disease severity and otherwise unrecognized cardiac injury. The protocol excludes people with known coronary artery disease, cardiac devices, severe renal impairment, active infection, or other listed contraindications, focusing on detection of previously undetected cardiopulmonary involvement.

Why it matters

Who can join: the full rules

Inclusion Criteria:

• Adult subjects (\>18 y.o.) with previously known ILD or high likelihood for having ILD including CTD diagnosis since at least 5 years before the project starts in order to increase the prevalence of ILD \[2\] who signed an Informed Consent authorizing data collection.

Exclusion Criteria:

* Subjects with active infectious disease;
* known CAD;
* history of previous percutaneous or surgical revascularization;
* known cardiomyopathy;
* previous heart failure;
* presence of cardiac devices (prosthetic valve, ICD, PM, ICD-CRT, LVAD)
* previous or active neoplasia;
* pregnancy and breastfeeding;
* allergy to iodine contrast agent;
* claustrophobia;
* glomerular filtration rate \< 30mL/min
* impossibility to lay down or breath old
* absence of informed consent signed

Where it's running

• IRCCS San Raffaele
  Milan, Italy Recruiting

Study contacts

• Study coordinator: Anna Palmisano
• Email: palmisano.anna@hsr.it
• Phone: 0226436106

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.