Photon-counting CT versus traditional CT for suspected coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized interventional trial compares two CT imaging technologies for evaluating suspected CAD. Participants with a clinical indication for CCTA are assigned to undergo CCTA with either photon-counting CT or conventional energy-integrating detector CT. The goal is to see if the photon-counting approach improves diagnostic accuracy and reduces unnecessary downstream testing or invasive procedures. The study focuses on how improved image quality and reduced artifacts may affect stenosis classification and subsequent treatment decisions. The trial is conducted at a Milan-based imaging center, led by IRCCS San Raffaele, with eligibility limited to adults without severe renal impairment who meet current ESC guidelines.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* clinical indication to perform CCTA for CAD assessment according to 2024 ESC Guidelines

Exclusion Criteria:

* Refusal to participate in the study
* Age \<18 years old
* Severe reduction in eGFR (\<30 mL/min)

Where it's running

• Advanced Imaging for Personalized Medicine/Radiologia DiMer
  Milan, Milano, Italy Recruiting

Study contacts

• Study coordinator: Antonio Esposito, prof. Dr.
• Email: esposito.antonio@hsr.it
• Phone: +39 02-26432643

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.