Registry for patients with poor grade aneurysmal subarachnoid hemorrhage
Poor Grade Aneurysmal Subarachnoid Hemorrhage Multicentric Study Group
This study is trying to understand how to better treat and predict outcomes for patients with severe brain bleeding caused by aneurysms, looking at both immediate and long-term effects.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 800 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS San Raffaele Academic / other |
| Locations | 10 sites (Bergamo and 9 other locations) |
| Trial ID | NCT04945603 on ClinicalTrials.gov |
What this trial studies
This multicentric registry aims to define outcomes, predictors, treatment effects, and modifiers in patients suffering from poor grade aneurysmal subarachnoid hemorrhage. The research focuses on three main areas: early brain injury predictors in the emergency department, delayed brain injury predictors in the neurocritical care unit, and treatment strategies. Additionally, it investigates the incidence and impact of delayed cerebral ischemia and the long-term follow-up of patients who may experience significant improvement after 6-12 months. Standard management will be provided according to established guidelines.
Who should consider this trial
Good fit: Ideal candidates include patients aged 18 and older admitted for poor grade aneurysmal subarachnoid hemorrhage classified as IV-V according to the WFNS classification.
Not a fit: Patients younger than 18, pregnant or breastfeeding women, and those with aneurysmal subarachnoid hemorrhage due to trauma or vascular malformations other than cerebral aneurysms may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve understanding of treatment outcomes and predictors, leading to better management strategies for patients with poor grade aneurysmal subarachnoid hemorrhage.
How similar studies have performed: Other studies have explored similar predictors and outcomes in subarachnoid hemorrhage, suggesting that this approach has potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients admitted to the emergency department because of aneurysmal subarachnoid hemorrhage of poor grade (IV-V) according to the WFNS classification. Exclusion Criteria: * Patients younger than 18 years old. * Pregnant or breast-feeding patients. * Aneurysmal subarachnoid hemorrhage due to trauma or vascular malformations other than cerebral aneurysms.
Where this trial is running
Bergamo and 9 other locations
- ASST Ospedale Papa Giovanni XXIII — Bergamo, Italy (Active_not_recruiting)
- IRCCS Bellaria — Bologna, Italy (Recruiting)
- Azienda Ospedaliera Spedali Civili — Brescia, Italy (Recruiting)
- Ospedale Vito Fazzi — Lecce, Italy (Recruiting)
- IRCCS San Raffaele — Milan, Italy (Recruiting)
- Ospedale Maggiore della Città di Novara — Novara, Italy (Recruiting)
- Azienda Ospedaliero-Universitaria di Parma — Parma, Italy (Recruiting)
- Policlinico Universitario Agostino Gemelli — Roma, Italy (Active_not_recruiting)
- Ospedale Santissima Annunziata — Taranto, Italy (Recruiting)
- Azienda Ospedaliera Universitaria Integrata — Verona, Italy (Recruiting)
Study contacts
- Principal investigator: Pietro Panni, P.I., M.D. — Department of Neuroradiology, Department of Neurosurgery
- Study coordinator: Pietro Panni, P.I., M.D.
- Email: panni.pietro@hsr.it
- Phone: +393406311389
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.