Characterizing immune cells in malignant brain tumors
Immunophenotype Characterization of Circulating and Tumor Infiltrating Immune Cells in Malignant Brain Tumors.
This study is trying to understand how immune cells behave in people with malignant brain tumors by looking at their blood and tumor samples before and after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS San Raffaele Academic / other |
| Locations | 1 site (Milan, Milan) |
| Trial ID | NCT05831631 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the immune cell profiles in patients with malignant brain tumors, focusing on both circulating leukocytes and tumor-infiltrating T cells. Participants will undergo blood sampling before surgery and continue with follow-up samples for 12 months, alongside tumor sample analysis. The goal is to correlate immune cell characteristics with oncological outcomes, providing insights into the immune response in high-grade gliomas and brain metastases.
Who should consider this trial
Good fit: Ideal candidates include adult patients (≥18 years) with primary or secondary malignant brain tumors who require neurosurgical treatment.
Not a fit: Patients who do not meet the inclusion criteria or are unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of immune responses in brain tumors, potentially leading to improved treatment strategies.
How similar studies have performed: While there have been studies on immune profiling in various cancers, this specific approach in malignant brain tumors is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Adult patients (≥18 years) * Able to express informed consent * With primary or secondary malignant brain tumor * Requiring neurosurgical treatment (radiosurgery, stereotactic biopsy, surgery) Exclusion Criteria: * Patients who do not meet inclusion criteria.
Where this trial is running
Milan, Milan
- IRCCS San Raffaele Scientific Institute — Milan, Milan, Italy (Recruiting)
Study contacts
- Study coordinator: Laura Sincinelli
- Email: sincinelli.laura@hsr.it
- Phone: 0226435568
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.