Genetic and blood markers linked to Menière's disease and symptoms
Genetics and Biohumoral Factors in Menière's Disease
This project will test whether common gene variants and blood markers that control inner-ear ion balance differ between people with Menière's disease, people with vestibular migraine, and people without vestibular disorders.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS San Raffaele Academic / other |
| Locations | 1 site (Milan, Italy) |
| Trial ID | NCT07518069 on ClinicalTrials.gov |
What this trial studies
This observational study enrolls adults with definite Menière's disease, a comparison group with vestibular migraine, and non-vestibular controls, primarily in an Italian (Caucasian) population. Researchers collect a blood sample for genetic testing of polymorphisms in genes involved in ionic homeostasis (for example KCNQ1 and KCNE1) and measure biohumoral markers. Genetic and blood-marker profiles will be compared across groups to look for correlations with clinical phenotypes such as episodic vertigo and fluctuating hearing loss. Participants who previously had ear surgery or intratympanic steroid or gentamicin therapy are excluded.
Who should consider this trial
Good fit: Adults of Caucasian/Italian background with definite Menière's disease by Barany Society criteria who have not undergone ear surgery or intratympanic steroid/gentamicin therapy.
Not a fit: People who have had prior ear surgery or intratympanic treatments, or those without Menière's disease, are unlikely to benefit from the study's findings.
Why it matters
Potential benefit: If successful, this could identify genetic or blood markers that help diagnose Menière's disease earlier or predict symptom patterns to guide care.
How similar studies have performed: Previous genetic studies targeting inner-ear ion channels have been attempted but produced no definitive markers, so this remains an exploratory area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with definite Menière's Disease according to the criteria of the Barany Society Exclusion Criteria: * surgically treated before the examination or if they had undergone intratympanic therapy with steroids or gentamicin
Where this trial is running
Milan, Italy
- IRCCS San Raffaele — Milan, Italy, Italy (Recruiting)
Study contacts
- Study coordinator: Roberto Carlo Teggi, MD
- Email: teggi.roberto@hsr.it
- Phone: +393921569410
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.