Understanding the causes of sarcopenic obesity in older adults
Dissecting the Molecular and Cellular Pathophysiology of Sarcopenic Obesity in the Elderly
IRCCS San Raffaele · NCT06320158
This study looks at how obesity and loss of muscle in older adults are connected and what causes this problem, focusing on people who are having hip surgery and healthy seniors.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1108 (estimated) |
| Ages | 65 Years to 99 Years |
| Sex | All |
| Sponsor | IRCCS San Raffaele (other) |
| Locations | 1 site (Milan) |
| Trial ID | NCT06320158 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the molecular and cellular mechanisms behind sarcopenic obesity, a condition affecting the elderly characterized by the coexistence of obesity and reduced muscle mass. By evaluating patients who are candidates for hip surgery and healthy older adults, the study seeks to uncover how increased fat mass and decreased muscle tissue contribute to this growing public health issue. The research will focus on the interplay between chronic inflammation, hormonal changes, and metabolic alterations in skeletal muscle. Through clinical evaluations, the study hopes to provide insights into the pathophysiology of sarcopenic obesity.
Who should consider this trial
Good fit: Ideal candidates include elderly individuals aged 65 and older who are candidates for hip surgery or healthy older adults with specific BMI criteria.
Not a fit: Patients with inflammatory or neurological myopathies, acute heart failure, or active cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and management strategies for sarcopenic obesity, improving health outcomes for elderly patients.
How similar studies have performed: While the specific molecular mechanisms of sarcopenic obesity are not extensively studied, related research on obesity and sarcopenia has shown promising results in understanding these conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: patients who are candidates for hip surgery * patients who are candidates for hip surgery * age ≥ 65 years * patients able to give consent healthy subjects \- healthy subjects from the geriatric cohort studied in 2016-2017 who at that time were: were overweight (25 ≤ BMI \< 30 kg/m2) or obese (BMI ≥ 30 kg/m2) but had not yet developed sarcopenia Exclusion Criteria: All partecipants * unavailability to participate in the study * inflammatory or neurological myopathies * acute heart failure * active cancer
Where this trial is running
Milan
- Ospedale San Raffaele — Milan, Italy (RECRUITING)
Study contacts
- Study coordinator: Patrizia Rovere Querini, PhD, MD
- Email: rovere.patrizia@hsr.it
- Phone: +390226436095
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Sarcopenic Obesity