Improving safety and accuracy of brain biopsies for lymphoma patients
Improving Safety and Accuracy of Stereotactic Brain Biopsies in Primary Central Nervous System Lymphoma (PCNSL): Integration of Advanced MRI Patterns and Fluorescein Sodium Fluorescence
This study is testing if looking at MRI images can help doctors safely and accurately diagnose brain lymphoma in patients who might not be able to have regular biopsies.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 15 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS San Raffaele Academic / other |
| Locations | 1 site (Milan, Milan) |
| Trial ID | NCT06263361 on ClinicalTrials.gov |
What this trial studies
This study evaluates the MRI imaging characteristics of the peritumoral area in patients with primary central nervous system lymphoma (PCNSL) to correlate these findings with pathological results. By understanding different MRI patterns, the research aims to enhance the diagnostic potential for patients with deep-seated lesions who may not be eligible for traditional stereotactic biopsies. This observational study focuses on adult patients undergoing biopsy for newly diagnosed PCNSL, aiming to improve treatment outcomes through better diagnostic accuracy.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients who are undergoing stereotactic biopsy for newly diagnosed primary central nervous system lymphomas.
Not a fit: Patients with severe hepatic, renal, or cardiac dysfunction, recent myocardial infarction or stroke, or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and improved treatment options for patients with primary central nervous system lymphoma.
How similar studies have performed: While this approach is focused on improving diagnostic accuracy for a specific condition, similar studies have shown promise in enhancing biopsy techniques and imaging correlations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients, undergoing stereotactic biopsy for newly diagnosed PSNCLs Exclusion Criteria: * Severe hepatic dysfunction * Severe renal dysfunction * Severe heart failure * myocardial infarction and stroke within 90 days * Hyperreactivity against contrast agents * Pregnancy
Where this trial is running
Milan, Milan
- IRCCS San Raffaele Scientific Institute — Milan, Milan, Italy (Recruiting)
Study contacts
- Study coordinator: Laura Sincinelli
- Email: sincinelli.laura@hsr.it
- Phone: +390226435568
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.