Investigating the role of glutamate in glioblastoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on glioblastoma multiforme (GBM), the most aggressive type of primary brain tumor. It aims to analyze the levels of glutamate and its related enzymes in serum and cerebrospinal fluid (CSF) to understand their role in tumor growth and invasion. A total of 40 patients suspected of having GBM will undergo blood sampling and MRI imaging at baseline and during follow-up at 3, 6, and 9 months. The study will collect molecular biology data alongside oncological and imaging information to explore potential therapeutic targets.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients with a brain lesion suspected for GBM, candidate to gross total tumor resection (GTR), followed by radiotherapy and chemotherapy (concomitant and adjuvant).
* Patient able to provide informed consent.

Exclusion Criteria:

* Age \< 18 years
* Liver disease
* Severe anemia (Hb \<8mg/dl)
* Pregnancy

Where it's running

• IRCCS San Raffaele Scientific Institute
  Milan, Milan, Italy Recruiting

Study contacts

• Study coordinator: Sincinelli Laura
• Email: sincinelli.laura@hsr.it
• Phone: 0226436658

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.