Microwave ablation for treating small kidney and liver tumors
Official title: Retrospective and Perspective Analysis of Short, Medium and Long Term Clinical Performance of Patients Undergoing MicrowaveThermal Ablation for Treatment of Small Renal Tumors and Primary and Secondary Liver Neoplasms
Run by IRCCS San Raffaele · NCT03981497 · Data updated 2026-11-12
This study is testing whether microwave ablation can safely and effectively treat small kidney and liver tumors in patients while they continue their regular care.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | IRCCS San Raffaele Academic / other |
| Locations | 1 site (Milan) |
| Status | Recruiting |
| Started | February 28, 2018 |
| Main results expected | December 31, 2034 |
| Study ends | December 31, 2039 |
| Registry record updated | September 23, 2026 |
| Trial ID | NCT03981497 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 with small primary or secondary liver tumors or small kidney tumors that are not suitable for surgical resection.
✕Probably not a fit
Patients with extensive extrahepatic or extrarenal disease, or those with non-manageable coagulopathies, are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to gather data on the efficacy and safety of microwave ablation (MWA) for patients with primary and secondary liver malignancies and small renal tumors. It will evaluate the short, medium, and long-term clinical outcomes of patients undergoing MWA, comparing these results with existing literature on other treatment methods. Participants will continue their usual clinical care while data on their treatment and outcomes will be collected for analysis.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the effectiveness of microwave ablation as a treatment option for patients with small renal and liver tumors.
How similar studies have gone: Other studies have shown promising results with microwave ablation for similar conditions, indicating that this approach is supported by existing evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * \> 18 years with primary or secondary liver tumors or small kidney tumors that are not candidates for surgery or cannot be radically resected by surgery alone * Primary liver cancer: up to three liver nodules ≤ 3 cm * Secondary hepatic tumours: up to nodules ≤ 3 cm provided that the objective is complete hepatic clearance Renal tumours: single or multiple (von Hippel Lindau syndrome), \< 4 cm Exclusion Criteria: * pregnant women * non-manageable coagulopathies * Extended extrahepatic or extrarenal disease * for liver ablation: presence of bilio-digestive anastomosis
Where it's running
-
IRCCS Ospedale San Raffaele
Milan, Italy Recruiting
Study contacts
- Study coordinator: Francesco De Cobelli, MD
- Email: decobelli.francesco@hsr.it
- Phone: +390226432529
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.