Looking at blood markers linked to bone, muscle, and energy metabolism
Retrospective Monocentric Evaluation of Biomarkers Associated With Bone, Muscle and Energy Metabolism
IRCCS San Raffaele · NCT07454252
This project will look at past blood tests from adults to see if specific bone turnover and formation markers relate to muscle function and energy metabolism.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS San Raffaele (other) |
| Locations | 1 site (Milan, Italy) |
| Trial ID | NCT07454252 on ClinicalTrials.gov |
What this trial studies
This is a retrospective, single-center analysis of blood samples collected at IRCCS San Raffaele Hospital between January 1, 2006 and March 31, 2025. The work examines circulating bone formation markers (P1NP, osteocalcin, bone alkaline phosphatase) and resorption markers (CTx-I, NTx-I, DPD) alongside metabolic parameters and available clinical data. Statistical modeling will be used to explore interactions among bone, muscle, and energy metabolism, including possible links mediated by osteocalcin and adipokines. No interventions are performed because the project uses existing laboratory data and records.
Who should consider this trial
Good fit: Adults aged over 18 who had blood sampling performed at the Laboratory Medicine Service of IRCCS San Raffaele Hospital between January 1, 2006 and March 31, 2025 are eligible for inclusion.
Not a fit: People under 18, those without qualifying blood samples at the specified lab and dates, and patients seeking a treatment change are unlikely to receive direct benefit from this retrospective analysis.
Why it matters
Potential benefit: If successful, the analysis could improve understanding of how bone-derived signals relate to metabolism and help refine biomarker-based monitoring or risk stratification.
How similar studies have performed: Prior research has shown associations between osteocalcin and glucose metabolism and has used bone turnover markers clinically, but integrated statistical modeling of bone–muscle–energy interactions remains relatively exploratory.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years. * Blood sampling performed at the Laboratory Medicine Service of IRCCS San Raffaele Hospital, Milan, between January 1, 2006 and March 31, 2025. Exclusion Criteria: -Age \< 18 years
Where this trial is running
Milan, Italy
- IRCCS San Raffaele Hospital — Milan, Italy, Italy (RECRUITING)
Study contacts
- Study coordinator: Eleonora Sabetta, MD
- Email: sabetta.eleonora@hsr.it
- Phone: 0226435288
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Bone Remodeling, Energy Metabolism, Energy metabolism, Bone resorption markers, Bone turnover markers, Statistical modeling of metabolic interactions