Using advanced CT to find liver cancer spread from colorectal cancer
Official title: Role of Photon Counting CT in Detecting Liver Metastatis From Colorectal Cancer
Run by IRCCS San Raffaele · NCT06753903 · Data updated 2026-11-12
This study is testing a new type of CT scan to see if it can better find liver cancer spread in adults with colorectal cancer who haven't had a biopsy yet.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | IRCCS San Raffaele Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Milan) |
| Status | Recruiting |
| Started | March 24, 2025 |
| Main results expected | March 24, 2028 |
| Study ends | March 24, 2028 |
| Registry record updated | January 15, 2026 |
| Trial ID | NCT06753903 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years with non-biopsy-proven colorectal cancer who have undergone PCD-CT and multiparametric MRI.
✕Probably not a fit
Patients who are pregnant, breastfeeding, or have not undergone the required imaging protocols will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the effectiveness of Photon Counting Computed Tomography (PCD-CT) in detecting liver metastases in patients with colorectal cancer. The study focuses on adults over 18 years who have not had a biopsy-proven diagnosis of colon or colorectal carcinoma and have undergone CT scans using PCD-CT technology. By comparing the results with multiparametric MRI, the study seeks to improve the accuracy of liver metastasis detection, which is crucial for determining treatment options and potential surgical interventions.
Why it matters
Potential benefit: If successful, this study could enhance the detection of liver metastases, leading to better treatment decisions and improved survival rates for colorectal cancer patients.
How similar studies have gone: While the use of advanced imaging techniques like PCD-CT is promising, this specific approach is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult (\>18 years) * non- biopsy-proven colon/colorectal carcinoma * CT performed on a PCD-CT * MRI with multiparametric protocol and hepatospecific contrast media Exclusion Criteria: * pregnancy and breastfeeding * CT exam performed on a scan different from PCD-CT * absence of multiparametric MRI * MRI with non hepatospecific contrast agent * Absent informed consent signed
Where it's running
-
IRCCS San Raffaele
Milan, Italy Recruiting
Study contacts
- Study coordinator: Antonio Esposito, MD
- Email: esposito.antonio@hsr.it
- Phone: 0226436102
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.