Mechanistic clues about lupus from immune disorders
Official title: Mechanistic insights into systemic lupus erythematosus (SLE) pathogenesis from inborn errors of immunity
Funded at Seattle Children's Hospital · NIH-11449228 · Data updated 2026-11-12
This grant looks at why certain immune disorders in people with genetic immune problems lead to lupus-like symptoms, by studying patients and mouse models.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 18, 2019 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $756,756 |
| NIH project number | 2R01AR073938-06A1 |
| Project ID | NIH-11449228 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with STAT1 gain-of-function syndrome, people with SLE, and healthy controls.
✕Less likely to help
People without the studied conditions or not participating in sample collection may not benefit.
What this research studies
Researchers will compare immune patterns in people with STAT1 GOF syndrome, SLE, and healthy controls to see how immune cells behave differently. They will track where autoantibodies come from using a new lineage-tracing method in mice and human samples. They will also study which immune cells and tissue environments drive inflammation, using advanced single-cell and spatial analysis. The goal is to uncover shared immune pathways that could guide treatments for lupus and related conditions.
Why it matters
Potential benefit: If successful, findings could inform new approaches to treat lupus and similar autoimmune diseases, including rare genetic forms.
How similar studies have gone: This work builds on prior findings linking STAT1 GOF and lupus-like autoimmunity, with a described multi-aim approach in both human and mouse models.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Jackson, Shaun William — Seattle Children's Hospital
- Study coordinator: Jackson, Shaun William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.