Understanding cardiovascular health in children and adults with lupus
Cardiovascular health assessment & outcomes of systemic lupus erythematosus: bridging pediatric and adult- onset disease
This study is looking at how childhood lupus can impact heart health by checking blood pressure at night, and it aims to find better ways to spot and treat heart risks for kids with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11094482 on NIH RePORTER |
What this research studies
This research investigates how systemic lupus erythematosus (SLE), particularly when it begins in childhood, affects cardiovascular health. It focuses on measuring nocturnal blood pressure decline using ambulatory blood pressure monitoring, which may indicate early cardiovascular risk. By identifying the mechanisms behind cardiovascular issues in these patients, the study aims to develop non-invasive measures and potential treatments to improve vascular health. The research also explores the effectiveness of specific medications that could help manage these risks.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and young adults diagnosed with pediatric-onset systemic lupus erythematosus.
Not a fit: Patients without a diagnosis of systemic lupus erythematosus or those with adult-onset lupus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cardiovascular health outcomes for patients with systemic lupus erythematosus.
How similar studies have performed: Previous research has shown promising results in using nocturnal blood pressure decline as a cardiovascular risk marker in other populations, suggesting potential success for this approach.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chang, Joyce Chun-Ling — Boston Children's Hospital
- Study coordinator: Chang, Joyce Chun-Ling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.