Understanding cardiovascular health in children and adults with lupus
Official title: Cardiovascular health assessment & outcomes of systemic lupus erythematosus: bridging pediatric and adult- onset disease
Funded at Boston Children's Hospital · NIH-11094482 · Data updated 2026-11-12
This study is looking at how childhood lupus can impact heart health by checking blood pressure at night, and it aims to find better ways to spot and treat heart risks for kids with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2020 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $75,587 |
| NIH project number | 3K23HL148539-05S1 |
| Project ID | NIH-11094482 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and young adults diagnosed with pediatric-onset systemic lupus erythematosus.
✕Less likely to help
Patients without a diagnosis of systemic lupus erythematosus or those with adult-onset lupus may not benefit from this research.
What this research studies
This research investigates how systemic lupus erythematosus (SLE), particularly when it begins in childhood, affects cardiovascular health. It focuses on measuring nocturnal blood pressure decline using ambulatory blood pressure monitoring, which may indicate early cardiovascular risk. By identifying the mechanisms behind cardiovascular issues in these patients, the study aims to develop non-invasive measures and potential treatments to improve vascular health. The research also explores the effectiveness of specific medications that could help manage these risks.
Why it matters
Potential benefit: If successful, this research could lead to improved cardiovascular health outcomes for patients with systemic lupus erythematosus.
How similar studies have gone: Previous research has shown promising results in using nocturnal blood pressure decline as a cardiovascular risk marker in other populations, suggesting potential success for this approach.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Chang, Joyce Chun-Ling — Boston Children's Hospital
- Study coordinator: Chang, Joyce Chun-Ling
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.