Condition
Lupus Nephritis clinical trials and research
Research outlook What's coming for Lupus: the next 6 months to 5 yearsAs of November 12, 2026, Find a Trial lists 43 Lupus Nephritis clinical trials that are recruiting, at sites in 35 countries (most in United States (18), China (13), Spain (6)). By phase: Phase 2 (9), Phase 1 (5), Phase 1/2 (5), Phase 4 (4). The most active sponsors are Tongji Hospital (3), Fate Therapeutics (2), Hoffmann-La Roche (2). There are also 47 NIH-funded research projects on Lupus Nephritis, with $27.7 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 43Clinical trials
- 47NIH research projects
- 35Countries
Newest Lupus Nephritis clinical trials
All recruiting trials (43)
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TranspoCART19 CAR-T therapy in adults with refractory lupus nephritis
This trial tests whether a patient’s own CD19 CAR-T cells can be safely given and potentially help adults with lupus nephritis that isn’t responding to standard treatments.
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Triple therapy with voclosporin, MMF and prednisolone in lupus nephritis
This trial tests whether adding voclosporin to standard lupus nephritis treatment (MMF and prednisolone) early on improves kidney inflammation compared to standard therapy alone.
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Biomarker tests in adults with lupus to see how kidney disease changes over time
Researchers will follow adults with lupus to see if blood and urine biomarkers can predict kidney involvement, flares, and treatment responses during routine care.
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LUPKYNIS in combination with belimumab, obinutuzumab, or anifrolumab for lupus nephritis
This trial tests whether adding LUPKYNIS to other biologics (belimumab, obinutuzumab, or anifrolumab) plus a mycophenolic acid analog and a steroid can rapidly improve kidney health in adults with biopsy-proven lupus nephritis.
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Mosunetuzumab for people with systemic lupus erythematosus
This study tests mosunetuzumab in people with systemic lupus erythematosus, with or without active lupus nephritis.
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FT819 in Lupus Nephritis: a targeted cell therapy trial for moderate-to-severe LN
This trial tests whether FT819, a donor-derived CAR T cell therapy, can help people with difficult-to-treat lupus nephritis who have not responded to other medicines.
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Biomarker-guided CAR-T target selection for refractory lupus
This trial tests whether using a lab-based immune profile to pick CD19- or BCMA-targeted CAR-T can help adults with refractory lupus, including lupus nephritis, who have not responded to standard treatments.
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Combining belimumab and voclosporin for proliferative lupus kidney disease
This trial will test whether giving belimumab and voclosporin together with background mycophenolate helps people with proliferative lupus nephritis reach complete kidney remission and lets doctors stop mycophenolate sooner.
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UB-VV410 for adults with active, treatment-refractory systemic lupus and lupus nephritis
This trial will test whether UB-VV410 is safe and how it acts in adults with active, treatment-refractory systemic lupus erythematosus, including those with lupus nephritis.
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Survey of LUPKYNIS (voclosporin) use in lupus nephritis
This survey will collect safety and effectiveness information about LUPKYNIS (voclosporin) in people who are newly starting treatment for lupus nephritis.
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Obe-cel for severe, treatment-resistant lupus nephritis
This study will test whether a single infusion of obe-cel, a CD19 CAR‑T cell therapy, can put adolescents and adults (ages 12–65) with severe, treatment‑resistant lupus nephritis into remission.
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Evaluating CTX112 for treating refractory autoimmune diseases in adults
This study is testing a new CAR T cell treatment called CTX112 to see if it can help adults with tough autoimmune diseases like lupus and scleroderma feel better.
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CAR T cell therapy for children with lupus nephritis
This study is testing a new CAR T cell therapy to see if it can help children with lupus nephritis who haven't responded to other treatments.
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CAR-T Cell Therapy for Lupus Nephritis
This study is testing a new CAR-T cell therapy to see if it can help people with tough-to-treat lupus nephritis feel better.
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Long-term follow-up of ianalumab with or without stopping treatment for people with lupus nephritis
This 2-year extension will test whether continuing or stopping ianalumab keeps kidney disease under control and is safe for people with lupus nephritis who completed the core study.
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Zamtocabtagene Autologous CAR-T for Autoimmune Diseases
This early-phase study tests whether a patient’s own CAR-T cells (zamto-cel) can be safely given after standard therapy to people with lupus or systemic sclerosis.
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Using CAR NK cells to treat adults with lupus nephritis
This study is testing a new CAR NK cell therapy to see if it can safely help adults with active lupus nephritis feel better.
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Assessing the effectiveness of belimumab for lupus nephritis treatment
This study is testing how well belimumab works for adults with active lupus nephritis to see if it helps protect their kidney function over time.
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Evaluating PRG-1801 for treating difficult cases of Lupus Nephritis and IgG4-Related Disease
This study is testing a new treatment called PRG-1801 to see if it can help adults with tough cases of Lupus Nephritis and IgG4-Related Disease feel better.
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Evaluating PRG-2311 for treating difficult cases of Lupus Nephritis and IgG4-Related Disease
This study is testing a new treatment called PRG-2311 to see if it can help people with tough cases of Lupus Nephritis and IgG4-Related Disease improve their kidney function and overall health.
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Combination treatment for autoimmune disorders using specialized cells and chemotherapy
This study is testing a new combination of specialized cells and chemotherapy to see if it can help people with autoimmune disorders like systemic sclerosis and lupus feel better.
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Evaluating QLG1074 for treating active lupus nephritis
This study is testing if a new treatment called QL1074 can help people with active lupus nephritis improve their kidney function when used alongside standard medications.
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Evaluating FT819 for autoimmune diseases
This study is testing a new treatment called FT819 to see if it can safely help people with moderate to severe autoimmune diseases feel better.
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FKC288 treatment for autoimmune kidney diseases
This study is testing a new treatment called FKC288 to see if it can help people with tough autoimmune kidney diseases like lupus nephritis and ANCA-associated vasculitis.
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CAR-T cell therapy for treating severe autoimmune diseases
This study is testing a new CAR-T cell therapy to see if it can help people with severe autoimmune diseases like lupus nephritis and vasculitis who haven't found relief with other treatments.
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Wellness and Coaching Support for Lupus Nephritis in Women of Color
This study tests whether culturally matched coaching delivered through a mobile app can help women of color with lupus or lupus nephritis improve self-management.
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Identifying biomarkers for lupus nephritis treatment response
This study is trying to find specific markers in blood and urine that can help predict how well people with lupus nephritis will respond to certain treatments.
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Using SGLT2 inhibitors to treat lupus nephritis in patients with chronic kidney disease
This study is testing if the medication dapagliflozin can improve kidney function in people with lupus nephritis and chronic kidney disease who are already receiving standard treatment.
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Evaluating CABA-201 for treating active systemic lupus erythematosus
This study is testing a new cell therapy called CABA-201 to see if it can help people with active lupus and kidney issues feel better and protect their organs.
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Cell injection therapy for active lupus nephritis
This study is testing a new cell injection therapy to see if it can help people with active lupus nephritis feel better while they continue their usual medications.
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Registry and biorepository for lupus patients
This study is gathering information and samples from over 3,500 people with lupus to help researchers learn more about the condition and improve treatments.
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Treatment of Lupus Nephritis in Children and Young Adults
This study is testing two different ways of giving a medication to see which one works better for children and young adults with lupus nephritis.
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Understanding genetic signatures in lupus nephritis patients
This study is trying to understand how certain genetic markers in people with lupus nephritis can help explain their disease and how their immune system is responding.
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Reducing glucocorticoid use in patients with lupus nephritis
This study is testing two different treatment plans for people with lupus nephritis to see which one helps reduce the use of steroids while still effectively managing their condition.
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VIB4920 treatment for active lupus nephritis
This study is testing if a new treatment called VIB4920, given with other medications, can help people with active lupus nephritis feel better and improve their kidney function.
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Evaluating Obinutuzumab for Lupus Nephritis in Adolescents
This study is testing if a medication called obinutuzumab can help teenagers with lupus nephritis feel better and improve their kidney health.
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Comparing treatments for lupus nephritis without added oral steroids
This study is testing whether a treatment for lupus nephritis using obinutuzumab and mycophenolate mofetil without steroids can work just as well as a treatment that includes steroids.
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Repeat kidney biopsy for lupus nephritis patients
This study tests whether doing repeat kidney biopsies can help doctors make better treatment decisions for patients with lupus nephritis by looking at tissue changes even when symptoms seem normal.
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A network for analyzing kidney biopsy data in glomerular diseases
This study is trying to build a detailed database of kidney biopsy samples and health information from patients with glomerular diseases to help researchers better understand these conditions and improve treatments.
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Using stem cells to treat lupus nephritis
This study is testing if bone marrow stem cells can help adults with lupus nephritis who haven't responded well to regular treatments feel better.
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Creating a database for patients with lupus nephritis in China
This study is creating a database of patients with lupus nephritis in China to gather important health information that can help improve care and understanding of the condition over time.
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Effects of Mycophenolate Mofetil and Cyclophosphamide on Lymphocyte Subsets in Lupus Nephritis
This study is testing whether two different medications, mycophenolate mofetil and cyclophosphamide, can change certain immune cells in people with lupus nephritis to see which treatment works better.
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Data repository for kidney diseases and related conditions
This study is collecting health information and samples from people with different kidney diseases to see how various factors affect their condition and treatment.
NIH-funded research (newest 40 of 47)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Glycoprotein urine markers that signal lupus nephritis treatment response
A novel test uses urine glycoprotein patterns to show how well lupus nephritis is responding to standard treatment.
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PTPRS and lupus nephritis: a new target to reduce kidney damage in lupus
Aims to understand how PTPRS contributes to kidney inflammation and scarring in lupus nephritis and explore targeting it to help patients.
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Sodium’s effect on kidney B cells in lupus kidney disease
This grant explores how high sodium in the kidneys affects B cells in lupus nephritis and whether blocking a key cellular pump could reduce kidney damage.
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Oral CD11b Activator for Lupus Nephritis
A new oral CD11b activating drug is being explored to help people with lupus nephritis by targeting immune pathways that cause kidney inflammation.
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Objective classification of lupus nephritis using computer vision
A new computer vision tool uses deep learning to classify lupus nephritis from kidney tissue images to help doctors predict outcomes for patients with lupus.
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AI-powered look at lupus nephritis in humans and mice
Researchers will use artificial intelligence to compare kidney tissue from people with lupus nephritis to tissue from mouse models, aiming to understand why treatments work differently in humans.
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miR-21 and B cells in lupus: how a tiny molecule can drive autoimmunity
Aims to understand how a microRNA called miR-21 influences B cells and kidney inflammation in lupus, with the goal of finding targeted therapies for people with SLE.
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Lupus Nephritis: How T cells cause kidney damage and how to stop them
A study at Yale will follow people and tissue samples to understand how certain immune cells cause kidney damage in lupus and explore ways to target them.
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Autoimmunity-Linked B Cells in Lupus Kidney Disease
A study to understand how a special immune cell subset called autoimmunity-associated B cells behave in lupus nephritis and how they may become antibody-making cells.
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Pharmacokinetically guided dosing of mycophenolate mofetil for pediatric lupus nephritis
A kid-focused trial will test whether adjusting mycophenolate mofetil dosing by pharmacokinetics improves kidney remission for children with proliferative lupus nephritis.
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Nanoparticles that target the kidney to treat lupus nephritis
This project delivers prednisolone directly to the kidney glomeruli using targeted nanoparticles to help people with lupus nephritis while reducing systemic side effects.
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Finding lupus kidney inflammation early with a urine protein test
Testing whether a urine protein test can detect early kidney inflammation in people with lupus before permanent damage occurs.
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New approaches to lupus-related kidney inflammation
This project looks at how immune cells and kidney cells interact to cause lupus-related kidney damage and explores targeted treatments for people with lupus nephritis.
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Looking closely at kidneys affected by lupus nephritis to learn what goes wrong
This work uses high-detail tissue mapping of kidney biopsies from people with lupus nephritis, including children, to find the specific cells and genes driving kidney damage.
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Digital analysis of kidney biopsy images for lupus nephritis
Using computerized analysis of digitized kidney biopsy images to find features that predict how lupus nephritis will behave in adults, especially people of African ancestry.
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Blocking iron-driven cell death in kidney tubules for lupus nephritis
Researchers aim to stop a type of iron-driven cell death in kidney tubules to help protect kidneys and lower the chance of kidney failure in people with lupus nephritis.
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Immune cells in lupus-related kidney inflammation
This project looks at different immune cells called myeloid cells in kidneys to learn how they cause or repair damage in people with lupus nephritis.
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More accurate lupus kidney diagnosis using new imaging biomarkers
This project uses two advanced imaging methods plus AI to help doctors read kidney biopsies more accurately for people with lupus nephritis.
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Using AI to better understand lupus kidney disease
This project uses advanced computer tools to compare kidney tissue from people and mice with lupus, hoping to find better ways to predict and treat the disease.
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Understanding how a tiny molecule affects lupus and kidney problems
This research explores how a small molecule called miR-21 contributes to lupus and its effects on the kidneys.
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Antibody sugar patterns in lupus kidney disease
Researchers are seeing whether unusual sugar decorations on antibodies lead to kidney damage in people with lupus.
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Oral pill that boosts CD11b to treat lupus-related kidney inflammation
An oral pill called ONTEGIMOD aims to activate a protein (CD11b) to reduce kidney inflammation in people with lupus nephritis.
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Treating blood-vessel damage in lupus-related kidney disease
Researchers are trying sepiapterin, a compound that may improve blood-vessel cell health and reduce kidney inflammation for people with lupus nephritis.
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Improving how we identify lupus kidney disease
This project uses computer technology to help doctors better identify and classify kidney disease in people with lupus.
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Understanding ABIN1 in Lupus Kidney Disease
This project looks at how a protein called ABIN1 contributes to lupus kidney disease, especially in African American patients, to find better ways to help them.
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Targeted treatment for kidney damage in lupus using nanoparticles
This study is testing a new way to treat lupus nephritis by using tiny particles to deliver medicine directly to the damaged parts of your kidneys, aiming to make treatment safer and more effective for people with this condition.
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Investigating B cells involved in lupus nephritis
This study is looking at special immune cells that can cause kidney problems in people with lupus, and it aims to learn how these cells work and what makes them harmful, so we can find better ways to treat lupus nephritis.
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Investigating how changes in IgG glycosylation affect kidney injury in lupus nephritis
This study is looking at how certain changes in antibodies might affect kidney health in people with lupus nephritis, hoping to find new ways to prevent kidney damage for those dealing with this condition.
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Investigating a new dosing method for treating pediatric lupus nephritis
This study is looking at how to make treatment better for kids with lupus kidney disease by comparing two ways of giving a medication called mycophenolate mofetil (MMF) to see which one helps their kidneys work better.
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Understanding lupus nephritis at the cellular level using advanced techniques
This study is looking at kidney tissue from kids with lupus nephritis to better understand how the disease affects them, with the hope of finding new treatments that work better for their specific needs.
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Using digital technology to analyze kidney biopsies in lupus nephritis patients
This study is looking to make it easier and more accurate to diagnose and manage kidney problems caused by lupus, especially for patients of African ancestry, by using advanced technology to better understand kidney biopsies and help doctors catch issues early so they can provide better care.
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Understanding and treating lupus nephritis
This study is looking into what causes kidney problems in people with lupus and how we can better treat it, especially for kids and those from minority backgrounds, by examining urine samples to find out how the immune system affects the kidneys.
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Improving kidney health in lupus nephritis by targeting cell death mechanisms
This study is looking at how too much iron in kidney cells can cause harmful cell death in people with lupus nephritis, and it aims to find new ways to help improve kidney health for those affected by this condition.
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Improving lupus nephritis diagnosis using advanced imaging techniques
This study is looking to improve how doctors diagnose lupus nephritis by combining regular tissue examination with new imaging technology, making it easier to spot important details in kidney tissue that can help with accurate diagnosis.
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Using urine tests to detect lupus nephritis early
This study is looking at urine samples from people with lupus to find early signs that could predict kidney problems before they happen, so that doctors can help prevent serious damage and offer safer treatments.
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Understanding myeloid cells in lupus nephritis
This study is looking at how certain immune cells in the body, called macrophages, affect kidney problems in people with lupus, and it hopes to find new ways to treat this condition by understanding these cells better.
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Using AI to understand lupus nephritis progression in humans and mice
This study is exploring how artificial intelligence can help us understand lupus nephritis better by comparing tissue samples from people and mice, with the goal of finding new ways to predict and improve treatments for this serious kidney condition.
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Preventing heart disease in patients with lupus nephritis
This study is looking to find better ways to prevent heart disease in Black patients with lupus nephritis, especially focusing on who might benefit most from certain treatments and how to make those treatments safer, particularly for young women who are pregnant.
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Investigating how sodium affects kidney B cells in lupus nephritis
This study is looking at how high sodium levels in the kidneys affect certain immune cells that can harm the kidneys in people with lupus nephritis, with the hope of finding new ways to help treat this condition.
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Investigating antibodies linked to modified nucleosomes in lupus nephritis
This study is looking at how certain antibodies in people with lupus nephritis can help doctors better understand the disease and improve diagnosis, using a new test that tracks these antibodies as the condition changes.
Related topics
Quick answers
How many Lupus Nephritis clinical trials are recruiting right now?
43, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 35 countries. The most sites are in United States (18 trials), China (13 trials), Spain (6 trials), France (5 trials), Brazil (4 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 9, Phase 1: 5, Phase 1/2: 5, Phase 4: 4. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.