Understanding how the immune system mistakenly attacks DNA in lupus
Mechanisms of DNA-Specific Autoimmunity in Systemic Lupus Erythematosus
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11061817
This study is looking at how a specific enzyme called DNASE1L3 affects the immune system in people with lupus, to better understand why some patients produce antibodies that attack their own DNA and how this can impact their health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11061817 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the immune system's production of antibodies that target DNA in patients with systemic lupus erythematosus (SLE). It focuses on a specific enzyme, DNASE1L3, which helps digest DNA in the body, and how its deficiency can lead to severe autoimmune reactions. By studying both human patients and mouse models, the research aims to uncover the clinical implications of these autoantibody responses and their role in disease progression. The team employs advanced techniques in immunology and patient phenotyping to gather comprehensive data.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus, particularly those experiencing severe symptoms or lupus nephritis.
Not a fit: Patients with other autoimmune diseases or those without a diagnosis of systemic lupus erythematosus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with systemic lupus erythematosus.
How similar studies have performed: Previous research has shown promising results in understanding autoimmune responses in similar contexts, indicating that this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REIZIS, BORIS — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: REIZIS, BORIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.