Improving medication adherence in adolescents with lupus using personalized feedback
Direct-to-family pharmacokinetics intervention for hydroxychloroquine non-adherence in adolescents with systemic lupus erythematosus
This study is looking to help teenagers with lupus take their medicine regularly by creating a digital tool that shows them how their medication works in their body, making it easier for them to understand why it's important to stick to their treatment plan.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10928505 on NIH RePORTER |
What this research studies
This research focuses on addressing the issue of medication non-adherence among adolescents with pediatric systemic lupus erythematosus (pSLE), particularly regarding the use of hydroxychloroquine (HCQ). The study aims to develop a digital intervention that provides personalized feedback based on pharmacokinetic simulations, helping patients understand their medication levels and encouraging them to take their medication as prescribed. By identifying a specific concentration cutoff for HCQ, the research seeks to create a reliable method for detecting non-adherence in clinical settings. The intervention will be tested for feasibility and preliminary effectiveness in a small group of adolescents, paving the way for larger trials in the future.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents diagnosed with pediatric systemic lupus erythematosus who struggle with medication adherence.
Not a fit: Patients who are not adolescents or those without a diagnosis of pediatric systemic lupus erythematosus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve medication adherence and health outcomes for adolescents with lupus.
How similar studies have performed: Previous research has shown promise in using digital interventions to improve medication adherence, suggesting that this approach could be effective.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Randell, Rachel Leigh — Duke University
- Study coordinator: Randell, Rachel Leigh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.