Understanding the causes of systemic lupus erythematosus through genetic studies across different ancestries
Official title: Integrative approaches to understand systemic lupus erythematosus etiology in trans-ancestry genetic studies
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-10887632 · Data updated 2026-11-12
This study is looking into the genetic reasons behind systemic lupus erythematosus (SLE), a condition that mainly affects young women, to help find better ways to diagnose it early and understand who might be at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | September 20, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $706,616 |
| NIH project number | 5R01AI174108-03 |
| Project ID | NIH-10887632 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include young women with a diagnosis of systemic lupus erythematosus or those at risk due to family history or genetic predisposition.
✕Less likely to help
Patients with autoimmune diseases other than systemic lupus erythematosus may not receive direct benefits from this research.
What this research studies
This research investigates the genetic factors contributing to systemic lupus erythematosus (SLE), an autoimmune disease that predominantly affects young women. By integrating genetic data from diverse populations, the study aims to identify causal variants associated with SLE and improve early diagnosis and risk prediction. The researchers will develop advanced statistical methods to analyze and combine data from various autoimmune diseases, enhancing the understanding of SLE's etiology. Additionally, they will create software tools to facilitate further research in this area.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of systemic lupus erythematosus, improving patient outcomes and quality of life.
How similar studies have gone: Previous research has successfully utilized similar integrative genetic approaches to uncover insights into other autoimmune diseases, suggesting a promising potential for this study.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Liu, Dajiang — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Liu, Dajiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.