Improving health outcomes for lupus patients by addressing social factors
Official title: Addressing Social Determinants of Health in Systemic Lupus Erythematosus
Funded at Polygon Health Analytics LLC · NIH-10921463 · Data updated 2026-11-12
This study is looking at how social factors affect the health of people with lupus, especially among different racial and ethnic groups, and aims to create a helpful tool that combines social support with medical care to improve health outcomes for patients.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Polygon Health Analytics LLC NIH-funded |
| Lab location | 1 site (Chalfont, United States) |
| Project start | September 22, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $295,924 |
| NIH project number | 1R43MD019614-01A1 |
| Project ID | NIH-10921463 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with systemic lupus erythematosus, particularly those from racial and ethnic minority groups or those facing social disadvantages.
✕Less likely to help
Patients with lupus who do not experience social determinants affecting their health or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research focuses on systemic lupus erythematosus (SLE), a complex autoimmune disease that affects various organ systems and presents differently in each patient. It aims to address the social determinants of health that contribute to disparities in SLE outcomes, particularly among racial and ethnic minorities. By utilizing real-world data and advanced artificial intelligence techniques, the project seeks to develop a tool that integrates social care into clinical management, ultimately improving patient care and health outcomes. The research involves collaboration between Polygon Health Analytics LLC and the University of Florida.
Why it matters
Potential benefit: If successful, this research could lead to improved health outcomes and quality of life for lupus patients by addressing the social factors that impact their care.
How similar studies have gone: Other research has shown success in using social determinants of health to improve patient outcomes, indicating that this approach has potential for meaningful impact.
Where this research is happening
-
Polygon Health Analytics LLC
Chalfont, United States Active
Researchers
- Principal investigator: Yao, Lixia — Polygon Health Analytics LLC
- Study coordinator: Yao, Lixia
Related research
Other NIH-funded projects on the same topics.
-
Immunostimulatory short non-coding RNAs and lupus
A study in people with lupus looks at tiny RNA pieces that may spark inflammation, to understand if they drive disease activity.
-
Antiviral factors that limit HIV in people with SLE
Researchers at Howard University are studying how immune factors in people with lupus may help limit HIV infection.
-
Mechanistic clues about lupus from immune disorders
This grant looks at why certain immune disorders in people with genetic immune problems lead to lupus-like symptoms, by studying patients and mouse models.
-
Subjective thinking challenges in adults with lupus as they age
This grant aims to understand how lupus-related cognitive problems affect adults, especially older adults, and tests a real-time method to track daily fluctuations in those symptoms.
-
Mitochondrial targets of antibodies in lupus (SLE)
A Johns Hopkins-led study will identify which mitochondrial membrane proteins are targeted by autoantibodies in lupus patients to understand how these immune attacks fuel the disease.
-
Influenza, Hydroxychloroquine, and the Windows of Self-Peptide Presentation in Lupus
A doctor-researcher is studying how flu infection and the lupus medication hydroxychloroquine change the way the immune system shows self-parts to trigger or prevent lupus flares in kids.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.