Condition

Antiphospholipid Syndrome clinical trials and research

• 22Clinical trials
• 3NIH research projects
• 9Countries

Newest Antiphospholipid Syndrome clinical trials

All recruiting trials (22)

• Thrombocytopenia Trajectories in antiphospholipid syndrome

  This study tests whether patterns in platelet counts over time can predict outcomes for adults with antiphospholipid syndrome.

  Recruiting New Valley University · Al Khārjah, Kharga Oasis · NCT07757789

• BCT301 CAR-iT cell therapy for hard-to-treat autoimmune diseases

  This early‑phase study tests whether off-the-shelf BCT301 CAR-iT cells can be given safely to adults with refractory autoimmune diseases to see if they can be tolerated and what dose works best.

  Recruiting Early Phase 1 Peking University Third Hospital · Beijing · NCT07301164

• Characterization of Autoreactive B Cells in Autoimmune Diseases and Immune Deficiencies

  Researchers are testing to see how autoreactive B cells behave in people with autoimmune diseases or immune deficiencies to better understand how these cells may contribute to disease.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07251179

• YTS109 cell therapy for relapsed or treatment‑resistant autoimmune diseases

  This will try a single infusion of YTS109 immune cells in adults 18–65 with relapsed or treatment‑resistant autoimmune diseases such as lupus, Sjogren’s, systemic sclerosis, inflammatory myopathies, or ANCA‑associated vasculitis.

  Recruiting at 2 sites Phase 1 China Immunotech (Beijing) Biotechnology Co., Ltd. · Xuzhou, Jiangsu and 1 other locations · NCT07236801

• YTS109 cell therapy for relapsed or refractory autoimmune diseases

  This will try a single infusion of YTS109 immune cells to see if they are safe and help adults 18–65 with relapsed or refractory lupus (including lupus nephritis), Sjogren's syndrome, inflammatory myopathy, or ANCA‑associated vasculitis.

  Recruiting Phase 1 China Immunotech (Beijing) Biotechnology Co., Ltd. · Bengbu · NCT07236762

• Antiphospholipid syndrome in people 65 and older who had an ischemic stroke

  This study will test whether routine blood testing for antiphospholipid antibodies in people aged 65 and over hospitalized with ischemic stroke or TIA can identify previously unrecognized antiphospholipid syndrome.

  Recruiting CHU de Reims · Reims · NCT07163338

• Hematological Markers MPV, PLR, and NLR in Primary Versus Secondary APS

  This study tests whether blood markers MPV, PLR, and NLR differ between people with primary antiphospholipid syndrome and those with APS secondary to another autoimmune disease.

  Recruiting New Valley University · Al Khārjah, Kharga Oasis · NCT07142239

• Butantan live tetravalent dengue vaccine for people with autoimmune rheumatic diseases

  This study will test whether a single dose of the Butantan live tetravalent dengue vaccine is safe and produces immune responses in clinically stable people aged 12–59 with autoimmune rheumatic diseases compared with matched healthy volunteers.

  Recruiting at 2 sites Phase 4 University of Sao Paulo General Hospital · São Paulo, São Paulo and 1 other locations · NCT07087912

• Universal CD19-targeting CAR-γδT cell therapy for refractory autoimmune diseases

  This trial will try infusing universal CD19-targeting CAR-γδT cells into adults with refractory B cell–driven autoimmune diseases to see if removing autoreactive B cells improves symptoms.

  Recruiting Phase 1/2 Peking University Third Hospital · Beijing · NCT06828042

• BCMA-CD19 CAR-T therapy for autoimmune diseases

  This study is testing a new CAR-T cell therapy to see if it can help adults with tough autoimmune diseases feel better and improve their health.

  Recruiting Phase 2 Peking University People's Hospital · Beijing, Beijing Municipality · NCT06794008

• Using engineered immune cells to treat difficult autoimmune diseases

  This study is testing if a new type of immune cell treatment can help people with tough autoimmune diseases that haven't responded to other therapies.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06614270

• YTS109 cell injection for autoimmune diseases

  This study is testing if YTS109 cell injections can help people with stubborn autoimmune diseases feel better and improve their health.

  Recruiting China Immunotech (Beijing) Biotechnology Co., Ltd. · Shanghai, Shanghai Municipality · NCT06379646

• Evaluating Annexin A2 on Monocytes in Antiphospholipid Syndrome

  This study is testing how a protein called Annexin A2 on immune cells might be linked to the causes of antiphospholipid syndrome in patients.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06373926

• Assessing diagnostic accuracy in antiphospholipid syndrome

  This study is trying to see if certain non-standard blood tests can help identify antiphospholipid syndrome in patients who have had blood clots or pregnancy issues, even if their regular tests come back negative.

  Recruiting Italian Society for Rheumatology · Roma, Rome · NCT06373003

• Registry for Antithrombotic Treatments in Patients with Antiphospholipid Syndrome

  This study is testing different blood-thinning treatments in people with antiphospholipid syndrome who had an artery problem in the last year to see which ones are safest and most effective.

  Recruiting at 3 sites McMaster University · Buenos Aires, Buenos Aires F.D. and 2 other locations · NCT05646394

• Using zanubrutinib to treat antiphospholipid syndrome with low platelet counts

  This study is testing if zanubrutinib can help people with antiphospholipid syndrome and low platelet counts who haven't found relief with other treatments.

  Recruiting at 2 sites Phase 2 Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality and 1 other locations · NCT05199909

• Registry and biorepository for rheumatic diseases

  This study is collecting samples and health information from adults with rheumatic diseases at Yale clinics to help researchers learn more about these conditions and improve future treatments.

  Recruiting Yale University · New Haven, Connecticut · NCT04402086

• Registry of patients with antiphospholipid antibodies

  This study is creating a registry to track adults with antiphospholipid antibodies to better understand their health and gather important information over time.

  Recruiting Central Hospital, Nancy, France · Lille and 1 other locations · NCT04308564

• Registry for patients with Antiphospholipid Syndrome treated with direct oral anticoagulants

  This study is collecting information from adults with Antiphospholipid Syndrome who have been taking blood thinners called direct oral anticoagulants to see how safe and effective they are for these patients.

  Recruiting Central Hospital, Nancy, France · Nancy · NCT04262492

• Gathering information on pediatric patients with Antiphospholipid Syndrome

  This study is gathering information on children with Antiphospholipid Syndrome to better understand its causes and treatments.

  Recruiting University of California, Davis · Sacramento, California · NCT00616317

• Identifying genetic risk factors for Antiphospholipid Syndrome

  This study is trying to find out if certain genes make people more likely to get Antiphospholipid Syndrome by looking at families where multiple members have APS or other autoimmune diseases.

  Recruiting Duke University · Durham, North Carolina · NCT00482794

• Predicting pregnancy outcomes in women with lupus and antiphospholipid syndrome

  This study is trying to see if certain proteins can help predict pregnancy outcomes for women with lupus and antiphospholipid syndrome.

  Recruiting at 4 sites Hospital for Special Surgery, New York · Chicago, Illinois and 9 other locations · NCT00198068

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How immune cells clear damaged mitochondria in antiphospholipid syndrome

  This project is seeing if fixing a cell-cleanup process in white blood cells can reduce harmful blood clots in adults with antiphospholipid syndrome.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11299104

• Decoding neutrophil membranes in antiphospholipid syndrome

  A patient-facing look at a study that aims to understand how neutrophils and cell membranes contribute to blood clots in antiphospholipid syndrome and how this could lead to new ways to diagnose and treat the condition.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11271719

• Investigating a protein linked to blood clotting and pregnancy complications

  This study is looking at a protein called beta-2 glycoprotein I to learn more about how it affects people with Antiphospholipid Syndrome, which can cause serious blood clots and pregnancy issues, so we can find better ways to diagnose and treat this condition.

  NIH research Saint Louis University · Saint Louis, United States · NIH-10762475

Related topics

Quick answers

How many Antiphospholipid Syndrome clinical trials are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in China (8 trials), France (5 trials), United States (4 trials), Egypt (2 trials), Canada (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 2, Early Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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