Investigating the effects of chlordecone exposure on systemic lupus erythematosus in Martinique
Systemic Lupus Erythematosus and Chlordecone Impregnation in Martinique
This study is trying to see if exposure to a pesticide called chlordecone affects how systemic lupus erythematosus (SLE) progresses in patients from Martinique.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital Center of Martinique Academic / other |
| Locations | 1 site (Fort-de-France) |
| Trial ID | NCT06365359 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between exposure to chlordecone, an organochlorine pesticide, and the progression of systemic lupus erythematosus (SLE) among patients in Martinique. It involves collecting blood samples to analyze the concentration of organochlorine pesticides and their potential impact on SLE activity. The study focuses on patients diagnosed with SLE who have been receiving care at the Martinique University Hospital for at least three years. By examining the effects of environmental contaminants on autoimmune diseases, the study seeks to provide insights into the health risks associated with chlordecone exposure.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with systemic lupus erythematosus who have been under care at the Martinique University Hospital for at least three years.
Not a fit: Patients without authenticated kidney disease or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of environmental factors contributing to systemic lupus erythematosus and inform future prevention strategies.
How similar studies have performed: While studies have explored the effects of environmental toxins on health, this specific investigation into chlordecone's impact on SLE is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with systemic lupus erythematosus according to the ACR 1997 or ACR/EULAR 2019 criteria, * Present in the active line of the internal medicine department of the Martinique University Hospital since 2005, * Whose illness has been progressing for at least 3 years, * Living in Martinique or Guadeloupe for at least 1 year, * Patients who have given their free, informed and written consent. Exclusion Criteria: * Patients for whom kidney disease cannot be authenticated or ruled out (refusal, contraindication or impossibility of renal biopsy), * Patients without social security coverage, * Current legal protection, * Patients who have not given their consent to the use of their data, * Pregnant or breastfeeding women.
Where this trial is running
Fort-de-France
- University Hospital Center of Martinique — Fort-de-France, France (Recruiting)
Study contacts
- Principal investigator: Benoît SUZON, PhD — University Hospital Center of Martinique
- Study coordinator: Benoît SUZON, PhD
- Email: benoit.suzon@chu-martinique.fr
- Phone: 05 96 55 97 05
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.