Checking HLA antibody results in people with lupus
HLA Antibodies in Systemic Lupus Erythematosus
This project will test how often people with lupus have false-positive anti-HLA antibody results and try lab methods to rule out those false positives.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Trial ID | NCT06921239 on ClinicalTrials.gov |
What this trial studies
This observational project will analyze stored serum samples from adult patients with systemic lupus erythematosus followed at Amiens University Hospital who have no history of pregnancy, transfusion, or transplant. Investigators will measure the prevalence of false-positive anti-HLA antibody detections in this lupus cohort and apply laboratory techniques intended to negate or identify those false positives. The work uses existing biobank samples and standard immunogenetics assays modified as needed to distinguish true anti-HLA sensitization from artefactual reactivity. Results will be descriptive and aimed at improving interpretation of HLA testing for transplant compatibility in autoimmune patients.
Who should consider this trial
Good fit: Adults with systemic lupus erythematosus who are followed in the internal medicine department at Amiens University Hospital and have serum stored in the hospital biobank, with no history of pregnancy, transfusion, or transplant.
Not a fit: Children, people without stored sera, or those with prior pregnancies, transfusions, or transplants are not eligible and may not benefit from the study findings.
Why it matters
Potential benefit: If successful, this could reduce false-positive HLA results and help more lupus patients be accurately considered for organ transplantation.
How similar studies have performed: Previous reports have documented false-positive HLA antibody results in autoimmune patients and some laboratory methods (for example adsorption or modified assay protocols) have reduced such reactivity, but data specifically focused on lupus cohorts remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients Adults * Followed in the internal medicine department of Amiens University Hospital - With systemic lupus erythematosus * Without HLA immunization risk factors (no history of pregnancy, transfusions or transplants) * With sera stored in the biobank Exclusion Criteria: * minor Patients * Opposing the re-use of their personal data for research purposes
Where this trial is running
Amiens
- CHRU Amiens — Amiens, France (Recruiting)
Study contacts
- Study coordinator: Nicolas GUILLAUME, Pr
- Email: guillaume.nicolas@chu-amiens.fr
- Phone: 33+322087046
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.