Investigating the role of specific proteins in Systemic Lupus Erythematosus
Official title: Nonreceptor tyrosine kinases in Systemic Lupus Erythematosus
Funded at State University New York Stony Brook · NIH-11077839 · Data updated 2026-11-12
This study is looking at how certain proteins in your body might be affecting your immune system if you have lupus, by checking for changes in these proteins that could make your symptoms worse, and it hopes to find new ways to help manage the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | May 25, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $315,637 |
| NIH project number | 5R01AI164424-05 |
| Project ID | NIH-11077839 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with severe Systemic Lupus Erythematosus.
✕Less likely to help
Patients with mild forms of lupus or other unrelated autoimmune conditions may not benefit from this research.
What this research studies
This research focuses on understanding how certain proteins, known as nonreceptor tyrosine kinases, affect the immune system in patients with Systemic Lupus Erythematosus (SLE). The researchers will study mutations in these proteins that may lead to improper immune responses and contribute to the severity of the disease. By examining cells from lupus patients and their healthy relatives, they aim to uncover how these mutations disrupt normal cellular functions, particularly in the process of clearing dead cells from the body. This could lead to new insights into the mechanisms of SLE and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the management of Systemic Lupus Erythematosus.
How similar studies have gone: Previous research has shown that targeting similar pathways in other autoimmune diseases has led to promising therapeutic advancements.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Miller, W Todd — State University New York Stony Brook
- Study coordinator: Miller, W Todd
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.