Investigating the role of specific proteins in Systemic Lupus Erythematosus
Nonreceptor tyrosine kinases in Systemic Lupus Erythematosus
This study is looking at how certain proteins in your body might be affecting your immune system if you have lupus, by checking for changes in these proteins that could make your symptoms worse, and it hopes to find new ways to help manage the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-11077839 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain proteins, known as nonreceptor tyrosine kinases, affect the immune system in patients with Systemic Lupus Erythematosus (SLE). The researchers will study mutations in these proteins that may lead to improper immune responses and contribute to the severity of the disease. By examining cells from lupus patients and their healthy relatives, they aim to uncover how these mutations disrupt normal cellular functions, particularly in the process of clearing dead cells from the body. This could lead to new insights into the mechanisms of SLE and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with severe Systemic Lupus Erythematosus.
Not a fit: Patients with mild forms of lupus or other unrelated autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the management of Systemic Lupus Erythematosus.
How similar studies have performed: Previous research has shown that targeting similar pathways in other autoimmune diseases has led to promising therapeutic advancements.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Miller, W Todd — State University New York Stony Brook
- Study coordinator: Miller, W Todd
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.