Clinical trial Recruiting at 1 site Interventional Ages 50 to 80

Evaluating lung cancer screening with CT scans in smokers

Official title: Evaluation of Lung Cancer CT Screening Performance Among Former and Current Smokers: a "Real Life" Study

Run by Hospital St. Joseph, Marseille, France · NCT05486455 · Data updated 2026-11-12

This study is testing if low-dose chest CT scans can help find lung cancer early in current or former smokers aged 50 to 80.

Quick facts

Study typeInterventional
Ages50 Years to 80 Years
SexAll
Enrollment1000 (estimated)
SponsorHospital St. Joseph, Marseille, France
Academic / other
Locations1 site (Marseille)
StatusRecruiting
StartedNovember 4, 2022
Main results expectedOctober 2028
Study endsOctober 2028
Registry record updatedDecember 6, 2022
Trial IDNCT05486455 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are men and women aged 50-80 who are current or former smokers with a history of at least 15 pack-years.

Probably not a fit

Patients who have had a chest CT scan in the past 12 months or those with a personal history of cancer within the last 5 years may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study assesses the effectiveness of low-dose chest CT scans combined with lung-RADS classification for screening lung cancer in individuals who are current or former smokers. It aims to determine the diagnostic performance of this approach in detecting lung cancer early among high-risk populations. Participants will undergo a CT scan to evaluate the presence of lung cancer, with a focus on those aged 50 to 80 who have a significant smoking history.

Why it matters

Potential benefit: If successful, this study could lead to improved early detection of lung cancer in smokers, potentially saving lives.

How similar studies have gone: Other studies have shown success with similar low-dose CT screening approaches for lung cancer, indicating potential for effective early detection.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Male or female 50-80 years old
* Active smoker (≥ 15 PA) or former smoker (≥ 15 PA)

Exclusion Criteria:

* Recent history of chest CT scan (within 12 months)
* Person unable to climb 2 floors
* Weight \> 140kg
* Personal history of cancer \< 5 years (currently being monitored by thoracic imaging)

Where it's running

  • Hôpital Saint Joseph
    Marseille, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.