NIH-funded research R01 grant

Novel mobile tool to help people ambivalent about quitting smoking

Official title: Evaluation of a Novel mHealth Intervention for People Who Are Ambivalent About Quitting Smoking: A Randomized Controlled Trial

Funded at Kaiser Foundation Research Institute · NIH-11396514 · Data updated 2026-11-12

A smartphone app trial helps adults who aren’t ready to quit smoking to engage with proven cessation support and move toward quitting.

More Randomized Controlled Trial research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionKaiser Foundation Research Institute
NIH-funded
Lab location1 site (Oakland, UNITED STATES)
Project startSeptember 1, 2024
Project endAugust 31, 2029
Funding year2026
Award (this year)$1,837,800
NIH project number4R01CA293229-03
Project IDNIH-11396514 on NIH RePORTER

Who could benefit from this research

Could help

Adults 21 years and older who smoke and are ambivalent about quitting.

Less likely to help

People who are already committed to quitting or who do not use mobile apps may see little benefit.

What this research studies

This trial tests a mobile health app called GEMS that delivers self-guided, theory-based exercises to adults who smoke and feel ambivalent about quitting. Participants are randomly assigned to use the app versus a control condition, with follow-up over time to see if engagement leads to reduced smoking or increased use of evidence-based treatments. The study builds on prior digital smoking-cessation work and emphasizes scalable, low-cost delivery that could reach many smokers. The trial aims to connect ambivalent individuals with available treatments when they’re ready to quit and to support them through the quitting process.

Why it matters

Potential benefit: If successful, the app could provide a scalable way to reduce smoking rates among people who are not yet ready to quit.

How similar studies have gone: Previous digital-therapy approaches have shown promise, but this study tests a novel, theory-based mHealth intervention in a real-world ambivalent-smoking population.

Where this research is happening

  • Kaiser Foundation Research Institute
    Oakland, United States
    Active

Researchers

  • Principal investigator: Mcclure, Jennifer B — Kaiser Foundation Research Institute
  • Study coordinator: Mcclure, Jennifer B

Related research

Other NIH-funded projects on the same topics.

  • Smartphone quit-smoking program for American Indian and Alaska Native adults

    This project tests a smartphone app based on Acceptance and Commitment Therapy to help American Indian and Alaska Native adults quit smoking compared with the NCI QuitGuide app.

    NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11170566

  • Mobile app to support smokers who are unsure about quitting

    A phone app offering short, guided exercises and links to quitting support for adult smokers who are unsure about quitting.

    NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11169778

  • Using exenatide with nicotine patches to help people quit smoking and manage weight gain.

    This study is looking at how well using exenatide, a medication that helps with appetite and blood sugar, along with nicotine patches can help people quit smoking while also managing weight gain that often happens after quitting.

    NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11101271

  • A new app to help people with serious mental illness quit smoking.

    This study is testing a friendly mobile app called Learn to Quit, which helps people with serious mental illnesses like schizophrenia and bipolar disorder to stop smoking by using helpful techniques and support.

    NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11066934

  • Helping people who are unsure about quitting smoking through a mobile app

    This study is testing a friendly mobile app called GEMS that helps adults who are unsure about quitting smoking by offering fun exercises and support to think about quitting when they're ready.

    NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-10936438

  • A digital app to help American Indians and Alaska Natives quit smoking

    This study is testing a smartphone app that helps American Indians and Alaska Natives quit smoking by offering support and resources based on proven techniques, and it's designed to make it easier for them to overcome challenges in stopping smoking.

    NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10932379

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.