Impact of Centrifuge Speed on Saliva Protein Levels in Smokers
Official title: Evaluating the Effect of Smoking Amount on Determining Salivary High Sensitive C-Reactive Protein(Hs-CRP) Values by Centrifuging the Saliva of the Same Individuals at Different Rpm and Time.
Run by Izmir Katip Celebi University · NCT06561971 · Data updated 2026-11-12
This study tests how different speeds of a machine that spins saliva samples can change the levels of a specific protein in the saliva of smokers and non-smokers to better understand the effects of smoking on oral health.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 30 Years |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Izmir Katip Celebi University Academic / other |
| Locations | 1 site (Izmir, Çiğli) |
| Status | Recruiting |
| Started | June 1, 2024 |
| Main results expected | August 1, 2024 |
| Study ends | January 22, 2025 |
| Registry record updated | December 20, 2024 |
| Trial ID | NCT06561971 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include systemically healthy individuals who are either non-smokers, light smokers (less than 10 cigarettes per day), or heavy smokers (more than 10 cigarettes per day) with no recent periodontal treatment.
✕Probably not a fit
Patients with oral or systemic diseases, those on regular medication, or individuals who have received recent periodontal treatment will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how different centrifuge speeds affect the levels of high sensitive C-reactive protein (hs-CRP) in saliva among individuals with varying smoking habits. It involves collecting saliva samples from 90 healthy participants categorized as non-smokers, light smokers, and heavy smokers. The samples will be centrifuged at different speeds to determine the optimal conditions for measuring hs-CRP levels and to explore any correlations with clinical parameters related to smoking. The study aims to enhance understanding of the biochemical effects of smoking on oral health.
Why it matters
Potential benefit: If successful, this study could provide insights into the relationship between smoking and inflammation, potentially guiding better oral health management for smokers.
How similar studies have gone: While there may be studies examining hs-CRP levels in relation to smoking, the specific focus on centrifuge speeds and saliva analysis in this context appears to be a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Systemically healthy * Periodontally clinical healthy * At least 20 permanent teeth in the mouth * No medication for continuous use * Those who have not used antibiotics, anti-inflammatory and systemic corticosteroid drugs in the last 6 months. * Not in pregnancy or lactation period. * Not received periodontal treatment in the last 6 months * For the non-smoker group; person who does not smoke tobacco * For the light-smoker group; person who smokes less than 10 cigarettes a day * For heavy-smoker group; person who smokes more than 10 cigarettes a day Exclusion Criteria: * Any oral or systemic disease * Regularly using a systemic medication * During pregnancy or lactation * Received periodontal treatment within the last 6 months. * Those who received antibiotic, anti-inflammatory or systemic corticosteroid medication in the last 6 months * Individual with periodontal disease
Where it's running
-
Izmir Katip Çelebi University Department of Periodontology
Izmir, Çiğli, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Ece Özer
- Email: ozerrece@gmail.com
- Phone: +90 5306958625
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.