Effects of e-cigarettes, nicotine pouches, menthol and nicotine on adults’ smoking and addiction
Official title: Evaluationg the effects of e-cigarettes vs. oral nicotine pouches and product constituents (menthol flavor, nicotine concentration) on adult cigarette smoking and addiction
Funded at Yale University · NIH-11394369 · Data updated 2026-11-12
This grant tests how different non-cigarette products and their ingredients affect smoking behavior in adults who currently smoke.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 30, 2013 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $347,171 |
| NIH project number | 5U54DA036151-14 |
| Project ID | NIH-11394369 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21+ who currently smoke and are willing to use non-combustible tobacco products under study conditions.
✕Less likely to help
Smokers who do not switch to or prefer not to use non-combustible products may not experience benefit.
What this research studies
Researchers at Yale plan a controlled trial involving adults who smoke to see how switching to non-combustible products like e-cigarettes or nicotine pouches, with varying flavors and nicotine levels, influences their smoking habits and addiction. The study aims to inform FDA regulatory decisions by studying how menthol flavor and nicotine concentration impact product use and substitution for cigarettes. Participants will be randomized to different product types and constituent profiles to observe changes in smoking behavior and related biomarkers. The findings could guide policies to reduce tobacco-related harm while helping people transition away from cigarettes.
Why it matters
Potential benefit: If successful, results could support regulatory decisions that reduce smoking-related harm and help adults transition away from cigarettes.
How similar studies have gone: Prior studies suggest regulatory-driven product changes can influence smoking behavior, but specific impacts of menthol and nicotine concentration on substitution require confirmation.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Fucito, Lisa M — Yale University
- Study coordinator: Fucito, Lisa M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.