Condition

Physical Inactivity clinical trials and research

• 49Clinical trials
• 3NIH research projects
• 14Countries

Newest Physical Inactivity clinical trials

All recruiting trials (49)

• Heat therapy during reduced activity to protect heart and muscle health

  A randomized trial tests whether daily Finnish dry sauna help preserves cardiovascular and muscle health when daily activity is reduced for seven days in healthy adults.

  Recruiting Brigham Young University · Provo, Utah · NCT07847424

• Alive Project: Does group exercise improve social life and health in 75+ women living alone?

  This study tests whether supervised group exercise at fitness clubs helps 75-year-old and older women who live alone feel less lonely and healthier compared to exercising alone or doing usual activities.

  Recruiting Norwegian School of Sport Sciences · Oslo, Oslo · NCT07789080

• See if short bursts of activity every day improve fitness and health in inactive young adults

  This study tests whether short, frequent bouts of exercise throughout the day can boost activity levels, fitness, and health in adults who aren’t currently active.

  Recruiting University of Wisconsin, River Falls · River Falls, Wisconsin · NCT07718113

• Motivating Activity Through Text Messages to Increase Movement

  This trial tests whether different motivational text messages can help adults aged 40+ move more, by tracking steps and activity over 6 months.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07593677

• Real-time app and wearable sensors to help young people control type 2 diabetes

  This project will try a smartphone app together with a continuous glucose monitor and a Fitbit for English-speaking 16–24-year-olds diagnosed with type 2 diabetes before age 18 to learn which messages and features help with activity and glucose monitoring.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07270016

• AI-powered fitness wearables and apps to boost activity in older adults living alone with cognitive decline

  This study tests whether an AI-driven fitness app and wearable program can help older adults living alone with cognitive decline be more physically active.

  Recruiting The University of Tennessee, Knoxville · Knoxville, Tennessee and 1 other locations · NCT07207993

• How COVID-19 affected fitness, sleep, diet, and blood pressure

  This project will see if past COVID-19 or long COVID is linked to changes in fitness, physical activity, blood pressure, sleep, and mental stress in adults aged 18 to 75.

  Recruiting Indiana University · Bloomington, Indiana · NCT07128095

• Choose to Move Replacement Ready for people waiting for hip or knee replacement

  This project will test whether the Choose to Move Replacement Ready program helps older adults on hip or knee replacement waitlists increase physical activity, improve mobility, and support psychosocial health.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07069179

• Smoking and daily physical activity in young adults

  This project will test whether more daily physical activity is linked to lower nicotine dependence among university students in health programs.

  Recruiting Saglik Bilimleri Universitesi · Istanbul · NCT07043920

• AI-guided postural rehabilitation for Parkinson's-related Pisa syndrome and camptocormia

  This project tests an AI-guided home rehabilitation program to improve posture for people with Parkinson's disease who have Pisa syndrome or camptocormia.

  Recruiting IRCCS National Neurological Institute "C. Mondino" Foundation · Pavullo nel Frignano, Pavia · NCT07010328

• Effects of physical activity on neuroinflammation in Parkinson's disease

  This study is testing if being physically active can help reduce inflammation in the brains of people with Parkinson's disease.

  Recruiting IRCCS National Neurological Institute "C. Mondino" Foundation · Pavia, Pavia · NCT06977204

• Using wearable devices to improve health in high-risk stroke patients

  This study is testing if smart wearable devices can help high-risk stroke patients manage their health better by reminding them to take medication, monitor their heart rate, and encourage exercise.

  Recruiting Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT06935513

• Actívatexto: Helping Latinos quit smoking and become more active

  This trial tests whether Actívatexto, a text-message program combined with wearables and nicotine replacement, helps Latino adults who smoke quit and increase their physical activity.

  Recruiting University of Rochester · Rochester, New York · NCT06926608

• Exploring physical activity in people with Parkinson's disease

  This study looks at how physical activity changes for people with Parkinson's disease in different situations to see what affects their activity levels and how to create better support for them.

  Recruiting Karolinska Institutet · Stockholm, Solna · NCT06901869

• Using robots to help older adults become more physically active

  This study is testing whether using robots can help older adults become more active by changing their automatic thoughts about physical activity.

  Recruiting University of Ottawa · Ottawa, Ontario · NCT06843161

• How Fitness and Body Fat Affect Blood Sugar and Blood Vessel Health After Short-Term Inactivity

  This study tests how existing fitness and body fat influence recovery of glucose control and vascular function after a period of reduced activity.

  Recruiting Miami University · Oxford, Ohio · NCT06842225

• Home-based prehabilitation program for liver transplant patients

  This study tests a home-based program that helps liver transplant patients get stronger and healthier before surgery to see if it improves their recovery and reduces complications.

  Recruiting Erasmus Medical Center · Rotterdam · NCT06808945

• Helping seniors with osteoarthritis use their SilverSneakers fitness benefits

  We will test whether a brief outreach with mailed materials and two phone calls helps older adults with osteoarthritis start using their SilverSneakers benefits, improve physical and social well-being, and reduce related healthcare use.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06782347

• Be Well at Work-PLUS: A Depression and Activity Program for Hospital Workers

  A workplace program tests whether a tailored depression and activity plan delivered by phone helps low-wage hospital staff improve mood and get more physical activity.

  Recruiting San Diego State University · San Diego, California · NCT06753123

• Exploring body image and physical activity in women with breast cancer

  This study looks at how breast cancer treatment affects body image and physical activity in Hungarian women to see how these changes impact their quality of life.

  Recruiting at 2 sites University of Pecs · Pécs, Baranya and 1 other locations · NCT06730815

• Impact of physical activity on surgery outcomes

  This study is trying to see if being more physically active before surgery can help adults avoid complications and live longer after having non-heart-related surgery.

  Recruiting Karolinska Institutet · Stockholm · NCT06678360

• Program to increase physical activity among low-resourced mothers

  This study is testing a program to help low-income mothers in New York City become more active by offering free fitness classes, childcare, and support from other moms.

  Recruiting at 3 sites Columbia University · New York, New York and 9 other locations · NCT06654843

• Examining how emotions affect physical activity engagement

  This study is trying out new ways to see if changing how people feel about exercise can help overweight or obese adults get more active.

  Recruiting University of Southern California · Los Angeles, California · NCT06570642

• Investigating the role of endothelin-1 in blood vessel function after gestational diabetes

  This study is testing how a substance called endothelin-1 affects blood vessel function in women who had gestational diabetes to see if insulin can help improve their heart health after pregnancy.

  Recruiting Early Phase 1 University of Iowa · Iowa City, Iowa · NCT06547619

• Effect of exercise on patients with chronic diseases

  This study is testing if regular exercise can help older adults with chronic diseases like COPD and diabetes feel better and improve their overall health.

  Recruiting Fundacion Universitaria Maria Cano · Medellín, Antioquia · NCT06476015

• Program to Increase Physical Activity in Stroke Survivors

  This study is testing if personalized counseling can help stroke survivors become more active compared to those who just get regular care.

  Recruiting Singapore General Hospital · Singapore, Singapore · NCT06409351

• Real-time engagement app to improve glycemic control in adolescents and young adults with type 2 diabetes

  A smartphone app that combines glucose, activity, and diet data is tested to see if it helps teens and young adults with type 2 diabetes manage their blood sugar better.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06375460

• Cognitive training to help middle-aged adults stick to exercise

  This study tests if a new brain training program can help middle-aged adults stick to their exercise routines better.

  Recruiting at 2 sites University of Iowa · Iowa City, Iowa and 1 other locations · NCT06338774

• Culturally tailored smartphone program to boost physical activity in African American women

  This study tests a smartphone program called Smart Walk to see if it can help African American women be more active and lower their risk of heart disease and diabetes.

  Recruiting Phase 2 Arizona State University · Phoenix, Arizona · NCT06337708

• Impact of Increased Physical Activity on Rheumatoid Arthritis Outcomes

  This study is trying to see if increasing physical activity after starting a new RA treatment helps people feel better and how fibromyalgia might change that.

  Recruiting Esbjerg Hospital - University Hospital of Southern Denmark · Esbjerg · NCT06289114

• Exploring how lifestyle factors relate to cardiovascular health

  This study looks at how things like exercise, stress, and diet affect heart health in both adults and children.

  Recruiting Istituto Auxologico Italiano · Milan · NCT06283069

• Impact of muscle loss on chemotherapy side effects in cancer patients

  This study is testing how muscle loss affects the side effects of chemotherapy in cancer patients to see if it makes treatment harder to handle.

  Recruiting Centre Hospitalier Metropole Savoie · Chambéry · NCT06274268

• Intervention to promote active travel among adolescents

  This study is testing a six-week program in schools to encourage teenagers to walk or bike more by teaching them about health and motivating them to be active.

  Recruiting Nordic Institute for Studies of Innovation, Research and Education · Oslo · NCT06156553

• Effects of T-REX Twente precautions on recovery after heart surgery

  This study is testing if following new T-REX Twente precautions helps people recover better and feel less afraid of moving after heart surgery compared to standard care.

  Recruiting Medisch Spectrum Twente · Enschede, Overijssel · NCT06115759

• Using augmented reality to encourage physical activity in children with cerebral palsy

  This study is testing whether an augmented reality app can help children with cerebral palsy be more active and enjoy exercising at home.

  Recruiting Children's Hospital Los Angeles · Los Angeles, California · NCT06096272

• Telehealth exercise program to treat depression after brain injury

  This study tests whether a telehealth exercise program can help people with depression after a brain injury feel better by encouraging them to be more active.

  Recruiting University of Washington · Seattle, Washington · NCT06005194

• Using prescribed physical activity to improve health in people with disabilities

  This study is testing whether a program that prescribes specific physical activities can help children and young people with disabilities, like autism and intellectual disabilities, improve their health and be more active.

  Recruiting Region Skane · Malmö · NCT05867940

• Reconstructing schoolyards to boost children's physical activity and address climate change

  This study is testing if making schoolyards greener can help kids in Stockholm be more active and improve their health over three years.

  Recruiting Karolinska Institutet · Stockholm · NCT05865782

• Personalized exercise program for cardiac outpatients

  This study is testing a personalized exercise program to see if it helps people with stable heart conditions improve their fitness and quality of life over time.

  Recruiting Università degli Studi di Ferrara · Ferrara, Ferrara · NCT05817305

• Improving physical activity in older adults living with HIV

  This study is testing three different ways to help older adults living with HIV be more active, including coaching, therapy for motivation, and a social support system using Fitbits, to see which method works best.

  Recruiting at 2 sites Butler Hospital · Minneapolis, Minnesota and 1 other locations · NCT05752500

• Program to help cancer survivors improve health behaviors

  This study is testing a new program to help cancer survivors improve their health habits, like losing weight and being more active, to see if it works better than regular care.

  Recruiting Northwestern University · Chicago, Illinois · NCT05687604

• Intervention to enhance active play in childcare centers

  This study is testing a new program to help childcare centers in British Columbia get kids moving more and developing their motor skills through active play.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT05669378

• Increasing daily steps through tailored communication

  This study is testing whether a mobile app that sends personalized messages can help inactive adults walk more and reach a daily goal of 7,000 steps.

  Recruiting University of Milano Bicocca · Milan, MI · NCT05620888

• Preventive physical activity for head and neck cancer patients

  This study tests if a special exercise program can help head and neck cancer patients feel better and function well during their radiation treatment.

  Recruiting Sahlgrenska University Hospital · Gothenburg · NCT05432297

• Improving positive emotions and physical activity after heart events

  This study is trying out a new program that combines positive thinking and motivation to help people recovering from heart events get more active and feel better compared to regular care.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05412862

• Program to support Indigenous women in improving health through physical activity

  This study is testing a program that helps Indigenous women improve their health through education and physical activity while also sharing cultural knowledge and building community support.

  Recruiting at 7 sites University of Calgary · Calgary, Alberta and 6 other locations · NCT05362435

• Examining health impacts of past sports injuries and inactivity

  This study is trying to see how past sports injuries and being inactive affect the long-term health of former athletes compared to non-athletes.

  Recruiting Marquette University · Milwaukee, Wisconsin · NCT05344001

• Effects of dietary phosphate on exercise and body fat

  This study is testing if eating less phosphate can help healthy adults exercise better and manage their body fat more effectively.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05147909

• Investigating the effects of aging on insulin resistance and obesity

  This study is testing how physical activity can help older adults aged 60-80 improve their insulin sensitivity and manage obesity as they age.

  Recruiting University of Lausanne · Bern and 1 other locations · NCT01224886

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How fitness and body fat affect recovery from low physical activity

  This study is looking at how your fitness level and body fat can affect how well you bounce back from high blood sugar and blood vessel issues after not being active for a while, and it's for anyone interested in understanding their health better.

  NIH research Miami University Oxford · Oxford, United States · NIH-11053645

• How lack of physical activity affects heart health through brain mechanisms

  This study is looking at how not being active can affect your heart health by focusing on a part of the brain that controls important signals in your body, and it hopes to find new ways to help people who are at risk for heart disease because they don’t get enough exercise.

  NIH research Wayne State University · Detroit, United States · NIH-10991379

• How early life inactivity affects muscle quality in adulthood

  This study looks at how not being active as a child can affect muscle health and overall well-being later in life, using mice to help us understand the long-term effects of early inactivity on things like muscle strength and aging.

  NIH research Miami University Oxford · Oxford, United States · NIH-10870721

Related topics

Quick answers

How many Physical Inactivity clinical trials are recruiting right now?

49, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (23 trials), Italy (5 trials), Sweden (5 trials), Canada (4 trials), Netherlands (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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