NIH-funded research U01 cooperative agreement

BSMAT: Helping people with HIV quit smoking through routine support

Official title: Botswana Smoking Abstinence Reinforcement Trial (BSMART)

Funded at University of Maryland Baltimore · NIH-11535385 · Data updated 2026-11-12

A HIV care program in Botswana aims to help people living with HIV quit smoking using a proven 5A brief intervention plus support medication.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionUniversity of Maryland Baltimore
NIH-funded
Lab location1 site (Baltimore, United States)
Project startSeptember 15, 2022
Project endAugust 31, 2027
Funding year2026
Award (this year)$47,271
NIH project number3U01CA275048-05S1
Project IDNIH-11535385 on NIH RePORTER

Who could benefit from this research

Could help

Adults living with HIV who smoke and receive care at participating HIV clinics.

Less likely to help

Individuals not interested in cessation or those outside the participating clinics may not benefit.

What this research studies

This project tests whether integrating a structured, lay-delivered SBIRT (Ask, Advise, Assess, Assist, and Arrange) with access to varenicline through HIV clinics can help people living with HIV in Botswana stop smoking and stay engaged in care. It uses a Type 2 hybrid design to measure both how well the intervention works and how easily clinics can adopt and maintain it in routine practice. Trained lay workers deliver the 5As, with nurse prescribers monitoring varenicline, to create a scalable, real-world approach to cancer prevention in HIV care. The study follows RE-AIM principles to evaluate reach, effectiveness, adoption, implementation quality, and maintenance, plus preliminary costs. Results could inform broader efforts to reduce smoking-related health risks in PLWH.

Why it matters

Potential benefit: If successful, this approach could reduce smoking-related health risks and improve overall health outcomes for people living with HIV.

How similar studies have gone: Previous research supports SBIRT and varenicline for smoking cessation, but this health-system–level implementation in HIV care is being tested in this context.

Where this research is happening

  • University of Maryland Baltimore
    Baltimore, United States
    Active

Researchers

  • Principal investigator: Charurat, Manhattan E — University of Maryland Baltimore
  • Study coordinator: Charurat, Manhattan E

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.