Research on lung cancer screening behaviors and outcomes in high-risk individuals in Taiwan

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on understanding the behaviors and outcomes of lung cancer screening among high-risk individuals in Taiwan, particularly those with a history of smoking, family history of lung cancer, or exposure to environmental pollutants. It utilizes low-dose computed tomography (LDCT) as a screening method to identify lung cancer in these populations. The study aims to gather real-world data to inform better screening strategies tailored to the unique risk profiles of participants, especially in the context of East Asian demographics. By analyzing the outcomes of these screenings, the research seeks to improve early detection and prevention efforts for lung cancer.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Group 1: Previous heavy smokers Age 50 to 80 years, meet both criteria in the followings.

1. Cigarette smoking of at least 20 pack-years
2. With successful smoking cessation history (stopping smoking for more than 6 months), but less than 15 years

Group 2: First-degree relatives of lung cancer patients

1. aged more than 50 years
2. age less than 50 years old, but older than the age at diagnosis of the youngest lung cancer proband in the family

Group 3: With other high-risk occupational or environmental factors Age 50 to 80 years, meet one or more of the following criteria.

1. air-pollution exposed occupations (such as traffic policemen, and street cleaners….) for at least 10 years
2. cooking index ≥ 110, defined as 2/7 \* days cooking by pan frying, stir-frying, or deep frying in one week \* years cooking.
3. cooking without using ventilation for more than 20 years
4. history of pulmonary tuberculosis and complete anti-tuberculosis treatment with intervals more than 5 years before this study

Exclusion Criteria:

1. previous history of lung cancer
2. another malignancy except for cervical carcinoma in situ or non-melanomatous carcinoma of the skin within 5 years
3. an inability to tolerate transthoracic procedures or thoracotomy
4. chest CT examination was performed within 18 months
5. hemoptysis of unknown etiology within one month
6. body weight loss of more than 6 kg within one year without an evident cause
7. a known pregnancy
8. Not capable of understanding or responding to the written questionnaire even through the help from the study team

Where it's running

• Chung Shan Medical University
  Taichung, Taiwan, Taiwan Recruiting
• National Taiwan University Hospital Hsin-Chu Branch
  Hsinchu, Taiwan Recruiting
• Hualien Tzu Chi Hospital
  Hualien City, Taiwan Recruiting
• Kaohsiung Medical University Chung-Ho Memorial Hospital
  Kaohsiung City, Taiwan Recruiting
• National Taiwan University Hospital
  Taipei, Taiwan Recruiting
• E-Da Hospital
  Kaohsiung City, Taiwan Not yet recruiting

Study contacts

• Study coordinator: GeeChen Chang, MD. PhD
• Email: geechen@gmail.com
• Phone: +886-4-24739595

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.