Research on lung cancer screening behaviors and outcomes in high-risk individuals in Taiwan
Taiwan Real-world Low-dose Computed Tomography Screening behavIor and Outcome Research for High Risk Subjects Based on Health Promotion Administration-part A: Questionnaire Survey -Part B: LDCT Screening Outcome and Management
This study looks at how high-risk individuals in Taiwan, like smokers or those with a family history of lung cancer, are getting screened for lung cancer using low-dose CT scans to see how effective these screenings are.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 6618 (estimated) |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Sponsor | Chung Shan Medical University Academic / other |
| Locations | 7 sites (Taichung, Taiwan and 6 other locations) |
| Trial ID | NCT05557487 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on understanding the behaviors and outcomes of lung cancer screening among high-risk individuals in Taiwan, particularly those with a history of smoking, family history of lung cancer, or exposure to environmental pollutants. It utilizes low-dose computed tomography (LDCT) as a screening method to identify lung cancer in these populations. The study aims to gather real-world data to inform better screening strategies tailored to the unique risk profiles of participants, especially in the context of East Asian demographics. By analyzing the outcomes of these screenings, the research seeks to improve early detection and prevention efforts for lung cancer.
Who should consider this trial
Good fit: Ideal candidates for this study include individuals aged 50 to 80 with a history of heavy smoking, first-degree relatives of lung cancer patients, or those exposed to significant environmental or occupational risks.
Not a fit: Patients who are not considered high-risk for lung cancer, such as lifelong non-smokers without family history or significant environmental exposure, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved screening strategies and early detection of lung cancer in high-risk populations, potentially reducing mortality rates.
How similar studies have performed: Other studies focusing on targeted lung cancer screening in high-risk populations have shown promise, indicating that tailored approaches can lead to better outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Group 1: Previous heavy smokers Age 50 to 80 years, meet both criteria in the followings. 1. Cigarette smoking of at least 20 pack-years 2. With successful smoking cessation history (stopping smoking for more than 6 months), but less than 15 years Group 2: First-degree relatives of lung cancer patients 1. aged more than 50 years 2. age less than 50 years old, but older than the age at diagnosis of the youngest lung cancer proband in the family Group 3: With other high-risk occupational or environmental factors Age 50 to 80 years, meet one or more of the following criteria. 1. air-pollution exposed occupations (such as traffic policemen, and street cleaners….) for at least 10 years 2. cooking index ≥ 110, defined as 2/7 \* days cooking by pan frying, stir-frying, or deep frying in one week \* years cooking. 3. cooking without using ventilation for more than 20 years 4. history of pulmonary tuberculosis and complete anti-tuberculosis treatment with intervals more than 5 years before this study Exclusion Criteria: 1. previous history of lung cancer 2. another malignancy except for cervical carcinoma in situ or non-melanomatous carcinoma of the skin within 5 years 3. an inability to tolerate transthoracic procedures or thoracotomy 4. chest CT examination was performed within 18 months 5. hemoptysis of unknown etiology within one month 6. body weight loss of more than 6 kg within one year without an evident cause 7. a known pregnancy 8. Not capable of understanding or responding to the written questionnaire even through the help from the study team
Where this trial is running
Taichung, Taiwan and 6 other locations
- Chung Shan Medical University — Taichung, Taiwan, Taiwan (Recruiting)
- National Taiwan University Hospital Hsin-Chu Branch — Hsinchu, Taiwan (Recruiting)
- Hualien Tzu Chi Hospital — Hualien City, Taiwan (Recruiting)
- E-Da Hospital — Kaohsiung City, Taiwan (Not_yet_recruiting)
- Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan (Recruiting)
- Ministry of Health and Welfare Shuang-Ho Hospital — New Taipei City, Taiwan (Not_yet_recruiting)
- National Taiwan University Hospital — Taipei, Taiwan (Recruiting)
Study contacts
- Study coordinator: GeeChen Chang, MD. PhD
- Email: geechen@gmail.com
- Phone: +886-4-24739595
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.