Inspire HER: a heart-health and stress-support program for Black women
Official title: Inspire HER: Inspiring the Heart and Emotions for Radical Health
Run by University of Alabama at Birmingham · NCT06966258 · Data updated 2026-11-12
This project will test whether the Inspire HER lifestyle program helps Black women with higher heart disease risk improve heart health and manage stress.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 30 Years to 79 Years |
| Sex | Women only |
| Enrollment | 90 (estimated) |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Locations | 1 site (Birmingham, Alabama) |
| Status | Recruiting |
| Started | November 15, 2025 |
| Main results expected | January 31, 2029 |
| Study ends | March 31, 2029 |
| Registry record updated | December 29, 2025 |
| Trial ID | NCT06966258 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are English-speaking Black women aged 30–79 who live in the metropolitan Birmingham, Alabama area and have stage 2 or greater cardiovascular-kidney-metabolic syndrome with no provider-imposed limits on physical activity.
✕Probably not a fit
People who are not Black women, live outside the Birmingham area, have provider-imposed limits on physical activity, or do not have elevated cardiometabolic risk are unlikely to benefit from participating.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Inspire HER is a 24-week lifestyle program adapted from Black Impact that combines regular physical activity, nutrition education, and connections to health coaches and community health workers. The team will refine the program using prior feedback and run a randomized, wait-list–controlled trial comparing Inspire HER to usual care among Black women with elevated cardiovascular-kidney-metabolic risk. The study will measure changes in heart-health metrics and biological responses to stress as primary outcomes, and will track self-reported stress, perceived health control, and unmet social needs as secondary outcomes. Investigators will also compare women's responses to existing Black Impact data in men to explore sex differences in stress and heart-health pathways.
Why it matters
Potential benefit: If successful, Inspire HER could lower cardiovascular risk and improve stress-related health and access to social supports for Black women.
How similar studies have gone: A similar program (Black Impact) showed promising improvements in heart health and stress-related outcomes in Black men in earlier studies, and a larger Black Impact trial is ongoing.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Black women (self-report) * Adult ages 30-79 years * Stage 2 or greater Cardiovascular-Kidney-Metabolic Syndrome * English speaking * Lives in Metropolitan Birmingham, AL area. Exclusion Criteria: \- Healthcare provider-imposed physical activity limitations.
Where it's running
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University of Alabama at Birmingham
Birmingham, Alabama, United States Recruiting
Study contacts
- Principal investigator: Timiya S Nolan, PhD — University to Alabama at Birmingha
- Study coordinator: LeAndrea D Anderson
- Email: leandreaanderson@uabmc.edu
- Phone: 205-996-0089
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.