How short steroid treatments change bone turnover markers in people with inflammatory joint disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows patients with inflammatory rheumatic joint disease who either start disease-modifying therapy with or without short-term glucocorticoids or receive a parenteral glucocorticoid injection while on stable DMARDs. Blood bone-turnover markers (BTMs) will be measured before, during, and after the short glucocorticoid exposure to document the size and timing of changes. Patients with prior osteoporosis, recent fractures, chronic steroid use, active cancer, or kidney failure are excluded to avoid confounding. The goal is to define how reliably BTMs reflect bone metabolism surrounding short steroid courses to guide clinical interpretation and management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* diagnosis of inflammatory rheumatic joint disease
* indication of disease modifying treatment initiation with or without glucocorticoids OR
* stable DMARD treatment with parenteral glucocorticoid injection

Exclusion Criteria:

* known osteoporosis or osteoporosis treatment
* women during the transitory phase
* oestrogen treatment
* any fracture within the last year
* chronic glucocorticoid treatment
* glucocorticoid treatment within the last year prior to inclusion
* active cancer
* kidney failure

Where it's running

• Vestre Viken HF, Drammen
  Drammen, Norway Recruiting
• Diakonhjemmet hospital
  Oslo, Norway Recruiting

Study contacts

• Study coordinator: Birgitte Nellemann Nellemann, MD PHD
• Email: birgittenellemann@gmail.com
• Phone: +4747957020

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.