Second hip fracture risk in Chinese patients with osteoporotic hip fractures
Second Hip Fracture Evaluation in Chinese Elderly Patients Using Quantitative Computed Tomography
This project will see if CT-based measurements of bone and muscle can predict second hip fractures in older adults who have already had an osteoporotic hip fracture.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Ages | 50 Years to 95 Years |
| Sex | All |
| Sponsor | Beijing Jishuitan Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT03461237 on ClinicalTrials.gov |
What this trial studies
This prospective observational study enrolls patients with surgically treated osteoporotic femoral neck or trochanteric hip fractures at Beijing Jishuitan Hospital. Participants will undergo quantitative CT (QCT) of the proximal femur to measure volumetric bone mineral density, bone structure, and surrounding muscle, with centralized image interpretation and quality control. The investigators will compare second-hip fracture rates by sex and fracture type and test whether QCT-derived metrics improve prediction of subsequent contralateral hip fractures. The study also aims to identify structural and muscle differences between femoral neck and trochanteric fractures during the healing process.
Who should consider this trial
Good fit: Ideal candidates are adults aged 47 or older with a surgically treated osteoporotic femoral neck or trochanteric hip fracture who can undergo CT imaging and provide informed consent.
Not a fit: Patients under 47, those with non-surgical repairs, pathologic or violence-related fractures, or with bilateral hip implants or a contralateral hip replacement are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the results could help clinicians identify patients at high risk for a second hip fracture so they can target prevention and closer monitoring.
How similar studies have performed: Prior work shows QCT measures of volumetric BMD and bone structure relate to fracture risk, but applying QCT specifically to predict second hip fractures has been less well studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * a:Osteoporotic patients b:Osteoporotic hip fracture patients (femoral neck fracture and femoral trochanteric fracture) c: Be willing to and be able to join in the study and sighed the informed consent Exclusion Criteria: * a:Under 47years old b:Non-surgical repair of hip fracture c:Pathologic fracture d:Violence-related trauma e:Bilateral hip implants or have hip replacement on the non-fractured side
Where this trial is running
Beijing, Beijing Municipality
- Beijing ji shui tan hospital — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Principal investigator: Xiaoguang Cheng, MD — department of radiology, Beijing Jishuitan Hospital
- Study coordinator: Xiaoguang Cheng, MD
- Email: xiao65@263.net
- Phone: 0086-010-58516947
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.