Analyzing bone damage in patients with osteoporosis and fragility fractures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the mechanisms of bone damage at the microscale in patients suffering from osteoporosis and fragility fractures. By utilizing advanced imaging techniques and computational models, the study seeks to understand how microstructural features of bone contribute to fracture risk. The research will involve patients undergoing primary hip replacement surgery, with a focus on validating computational models through experimental tests on human bones. The ultimate goal is to develop new fracture indices that can aid in early diagnosis and treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: \>=18 years
* primary hip replacement
* Signature of informed consent
* Patients who have a routine preoperative CT scan

Exclusion criteria:

* Patients unrelated to the inclusion criteria of this study
* Bone disease (non-osteoporotic) such as to invalidate sample analysis, including but not limited to genetic disorders and bone tumors
* Patients with contralateral hip replacement and/or other synthetic means in the contralateral hip
* Patients with synthesis devices in the hip of interest

Where it's running

• IRCCS Istituto Ortopedico Galeazzi
  Miano, Milano, Italy Recruiting

Study contacts

• Principal investigator: Luigi Zagra — IRCCS Istituto Ortopedico Galeazzi
• Study coordinator: Laura M Vergani
• Email: luigi.zagra@fastwebnet.it
• Phone: +393393758630

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.