Comparing Osteoporosis Medications for Safety and Effectiveness
Comparative Effectiveness and Safety of Osteoporosis Drug Therapies
This project helps us understand which osteoporosis medications work best and are safest for people at risk of broken bones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11129725 on NIH RePORTER |
What this research studies
Many people face the risk of broken bones due to osteoporosis, but concerns about long-term medication side effects can make it hard to stick with treatment. This project looks closely at different osteoporosis medications to see how well they prevent fractures over time and if they cause rare side effects like atypical femur fracture or jaw bone issues. We want to learn if taking breaks from medication or switching treatments can reduce these risks without making the medication less effective. The goal is to provide clearer information so patients and doctors can make better choices about long-term bone health.
Who could benefit from this research
Good fit: This research is relevant for adults, especially those 65 and older, who are at risk of osteoporotic fractures and are considering or currently using osteoporosis drug therapies.
Not a fit: Patients who do not have osteoporosis or are not candidates for drug therapy would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help patients and doctors make more informed decisions about osteoporosis treatment, potentially leading to better fracture prevention and fewer side effects.
How similar studies have performed: While large trials have shown osteoporosis drugs reduce fracture risk, there is less evidence on the long-term effectiveness and safety of specific strategies like drug holidays or sequential therapies.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Brito Campana, Juan P — Mayo Clinic Rochester
- Study coordinator: Brito Campana, Juan P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.