Effects of Different Exercise Types on Bone Health in Older Veterans

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how resistance and endurance exercise affect bone health in older veterans. It aims to determine whether resistance exercise leads to similar increases in bone resorption as endurance exercise and how exercise training influences these changes. The study will involve 60 healthy veterans aged 60-80, who will participate in 10 weeks of supervised resistance or endurance exercise training. Blood markers related to bone resorption and formation will be measured to assess the impact of these exercise modalities.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy older (60+ y) Veteran women and men in the Denver Metro Area
* Normally active (e.g., recreational cycling or walking exercise)

Exclusion Criteria:

* Impaired renal function, defined as an eGRF of \<60 mL/min/1.73m2
* Hepatobiliary disease, defined as liver function tests (AST, ALT) \>1.5 times the upper limit of normal
* Thyroid dysfunction, defined as an ultrasensitive thyroid stimulating hormone (TSH) \<0.5 or \>5.0 mU/L
* Serum Ca \<8.5 or \>10.3 mg/dL
* Serum 25(OH)D \<20 ng/mL
* Uncontrolled hypertension, defined as resting systolic blood pressure (BP) \>150 mmHg or diastolic BP \>90 mmHg;
* History of type 1 or type 2 diabetes
* Cardiovascular disease, defined as subjective or objective indicators of ischemic heart disease (e.g., angina, ST segment depression) or serious arrhythmias at rest or during the graded exercise test (GXT). Volunteers who have a positive GXT can be re-considered after follow-up evaluation, which must include diagnostic testing (e.g., stress echocardiogram or thallium stress test) with interpretation by a cardiologist
* Anemia, defined as a serum hemoglobin \<12.1 g/dL for women and \<14.3 g/dL for men
* Fracture in the past 6 months
* Current diagnosis or symptoms of COVID-19

In the event of abnormal BP, live function, TSH, 25(OH)D, or hemoglobin values, volunteers can be reassessed, including after appropriate follow-up evaluation and treatment by a primary care provider. Those who have experienced symptoms of COVID-19 or have been formally diagnosed will be allowed to participate once symptoms have resolved and they are approved to return to exercise by their primary care provider.

Where it's running

• Rocky Mountain Regional VA Medical Center, Aurora, CO
  Aurora, Colorado, United States Recruiting

Study contacts

• Principal investigator: Sarah J Wherry, PhD — Rocky Mountain Regional VA Medical Center, Aurora, CO
• Study coordinator: Sarah J Wherry, PhD
• Email: sarah.wherry@va.gov
• Phone: (720) 848-6475

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.