Understanding how bone cells respond to osteoporosis treatments
The role of the osteocyte in responses to osteoporosis anabolic treatment in humans and mice
['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11085960
This study is looking at how bone cells called osteocytes react to treatments for osteoporosis in post-menopausal women, with the hope of finding better ways to strengthen bones and improve current therapies.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11085960 on ClinicalTrials.gov |
What this research studies
This research investigates the role of osteocytes, the primary cells in bone, in how they respond to anabolic treatments for osteoporosis. By examining human biopsy samples from post-menopausal women with osteoporosis and conducting experiments in mice, the study aims to uncover the mechanisms behind the effectiveness and limitations of current osteoporosis therapies. The goal is to identify new therapeutic targets that could lead to improved treatments for bone fragility. The research will compare the responses of osteocytes at different time points to better understand their role in treatment efficacy.
Who could benefit from this research
Good fit: Ideal candidates for this research are post-menopausal women diagnosed with osteoporosis.
Not a fit: Patients with osteoporosis who are not post-menopausal or those with other underlying bone disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for osteoporosis, reducing fracture risk and improving bone health.
How similar studies have performed: Previous research has shown that understanding cellular responses in bone can lead to significant advancements in osteoporosis treatment, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARON, ROLAND E — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: BARON, ROLAND E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.