Drug or treatment

Denosumab clinical trials

• 13Clinical trials
• 9Countries

Newest trials

All recruiting trials (13)

• Ibandronate vs. Zoledronic Acid After Denosumab: Is Either Equal for Postmenopausal Osteoporosis?

  In postmenopausal osteoporosis, this study tests whether intravenous ibandronate given after stopping denosumab works as well as zoledronic acid over a year.

  Recruiting Phase 4 National Taiwan University Hospital · Taipei · NCT07406685

• Romosozumab and denosumab alone or together for postmenopausal osteoporosis

  This 6-month pilot tests whether cyclic romosozumab combined with denosumab improves bone density more than denosumab alone in postmenopausal women with osteoporosis.

  Recruiting Phase 4 National Taiwan University Hospital · Douliu, Taiwan · NCT07283887

• Denosumab effects on muscle strength and insulin sensitivity

  This trial will test whether denosumab improves muscle strength and insulin sensitivity in postmenopausal women with osteoporosis and type 2 diabetes who are taking metformin.

  Recruiting Phase 4 Aarhus University Hospital · Aarhus · NCT07271771

• Combining PD-1 immunotherapy, denosumab, and chemotherapy for advanced non-squamous lung cancer without targetable mutations

  This trial will test whether adding a PD-1 immunotherapy and denosumab to standard chemotherapy helps people with advanced non-squamous non-small cell lung cancer who do not have targetable driver mutations.

  Recruiting Phase 2 China Medical University, China · Shenyang, Liaoning · NCT07034391

• Comparing two treatment regimens for osteoporosis in postmenopausal women

  This study is testing two different treatment plans for osteoporosis in postmenopausal women to see which one helps improve bone strength and reduce the risk of fractures better.

  Recruiting Phase 4 National Taiwan University Hospital · Taipei · NCT06938152

• Zoledronate options after stopping denosumab in postmenopausal osteoporosis.

  This trial will test whether using a blood bone‑turnover marker to decide on extra zoledronate infusions better prevents spinal bone loss in postmenopausal women who stop denosumab.

  Recruiting at 16 sites Phase 4 University Hospital, Toulouse · Amiens and 16 other locations · NCT06767150

• Using denosumab to improve beta cell function in type 1 diabetes

  This study is testing if a medication called denosumab can help improve insulin production and blood sugar control in people with early type 1 diabetes.

  Recruiting at 3 sites Phase 1/2 City of Hope Medical Center · Birmingham, Alabama and 2 other locations · NCT06524960

• Using Denosumab to treat Fibrous Dysplasia and McCune-Albright Syndrome in adults

  This study is testing if Denosumab can help adults with Fibrous Dysplasia and McCune-Albright Syndrome feel less pain and improve their condition compared to a placebo.

  Recruiting Phase 4 Leiden University Medical Center · Leiden · NCT05966064

• Prevention and treatment of osteoporotic fractures

  This study is testing new ways to prevent and treat fractures in people with osteoporosis to see if they can improve care and outcomes.

  Recruiting at 58 sites Peking Union Medical College Hospital · Beijing and 57 other locations · NCT05866029

• Observing bone health in post-menopausal breast cancer patients after stopping certain treatments

  This study looks at how stopping certain breast cancer treatments affects bone health in post-menopausal women over two years.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05590949

• Preventing bone loss in critically ill adults using medications

  This study is testing if two medications can help prevent bone loss in critically ill adults over 50 who have been in the ICU for more than a day.

  Recruiting at 20 sites Phase 2 Australian and New Zealand Intensive Care Research Centre · Sydney, New South Wales and 21 other locations · NCT04608630

• Treatment of acute Charcot foot in diabetes patients with Denosumab

  This study is testing if Denosumab can help people with diabetes who have acute Charcot foot feel better and recover faster compared to those who get a placebo.

  Recruiting at 8 sites Phase 3 Bispebjerg Hospital · Aalborg and 7 other locations · NCT04547348

• Evaluating new treatments for osteoporosis after denosumab therapy in Japanese patients

  This study tests different treatment options for Japanese patients with osteoporosis who have been on denosumab for two years to see which one works best and is safe to use for another two years.

  Recruiting Phase 2 Shinshu University · Matsumoto, Nagano · NCT03755193

Quick answers

How many clinical trials of Denosumab are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in Taiwan (3 trials), China (2 trials), Denmark (2 trials), United States (2 trials), Japan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 6, Phase 2: 3, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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