Clinical trial Recruiting at 1 site Observational Ages 18 and up

Proximal Humerus Cortical Thickness in Post-Stroke Paresis

Official title: Radiographic Cortical Thickness of the Humerus in Detecting Post-Stroke Regional Bone Loss

Run by Istanbul Physical Medicine Rehabilitation Training and Research Hospital · NCT07651306 · Data updated 2026-11-12

This study tests whether measurements of the outer bone thickness of the upper arm (the humerus) on the paretic side after a stroke reflect regional bone loss and how well they agree with standard bone density tests.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment65 (estimated)
SponsorIstanbul Physical Medicine Rehabilitation Training and Research Hospital
Government
Drugs / interventionsradiation
Locations1 site (Istanbul)
StatusRecruiting
StartedFebruary 22, 2026
Main results expectedJune 25, 2026
Study endsJuly 1, 2026
Registry record updatedJune 16, 2026
Trial IDNCT07651306 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18 years or older with a history of a single unilateral stroke at least six months prior and clinical hemiparesis, who have both shoulder radiographs and DXA measurements available.

Probably not a fit

Patients without both shoulder radiographs and DXA data or with conditions/exclusions that affect bone measurement may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This cross-sectional, retrospective analysis examines whether proximal humerus cortical bone thickness differs between paretic and non-paretic arms in adults with a prior unilateral stroke and hemiparesis. Researchers will compare radiographic measurements from routine shoulder X-rays with systemic DXA bone density values to see if X-ray-based thickness can indicate regional bone loss. Data will come from patients 18 years and older who had a single stroke at least six months ago and have both shoulder radiographs and DXA data available within six months post-stroke. The study aims to determine if standard shoulder imaging could serve as an accessible screening tool for regional osteoporosis risk in the paretic arm.

Why it matters

Potential benefit: If successful, clinicians could use routine shoulder X-rays to screen for regional bone loss after stroke, potentially guiding prevention of fractures.

How similar studies have gone: Prior work supports the idea that imaging-based bone measurements can reflect bone health, but this specific shoulder radiograph–DXA correlation after stroke is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients aged 18 years and older.
* A documented history of a single unilateral stroke that occurred at least 6 months prior to evaluation.
* Presence of clinical hemiparesis.
* Availability of concurrent standard anteroposterior (AP) shoulder radiographs taken within 6 months post-stroke alongside systemic DXA measurements.

Exclusion Criteria:

* History of surgical intervention in either shoulder. History of a proximal humerus fracture.
* Co-existing metabolic bone diseases, such as primary hyperparathyroidism or osteomalacia.
* History of malignancy.
* Documented history of corticosteroid use.
* Imaging artifacts that compromise the accuracy of DXA measurements.
* History of a secondary stroke.

Where it's running

  • Istanbul Physical Medicine Rehabilitation Training and Research Hospital
    Istanbul, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.