Proximal Humerus Cortical Thickness in Post-Stroke Paresis
Official title: Radiographic Cortical Thickness of the Humerus in Detecting Post-Stroke Regional Bone Loss
Run by Istanbul Physical Medicine Rehabilitation Training and Research Hospital · NCT07651306 · Data updated 2026-11-12
This study tests whether measurements of the outer bone thickness of the upper arm (the humerus) on the paretic side after a stroke reflect regional bone loss and how well they agree with standard bone density tests.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 65 (estimated) |
| Sponsor | Istanbul Physical Medicine Rehabilitation Training and Research Hospital Government |
| Drugs / interventions | radiation |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | February 22, 2026 |
| Main results expected | June 25, 2026 |
| Study ends | July 1, 2026 |
| Registry record updated | June 16, 2026 |
| Trial ID | NCT07651306 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older with a history of a single unilateral stroke at least six months prior and clinical hemiparesis, who have both shoulder radiographs and DXA measurements available.
✕Probably not a fit
Patients without both shoulder radiographs and DXA data or with conditions/exclusions that affect bone measurement may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This cross-sectional, retrospective analysis examines whether proximal humerus cortical bone thickness differs between paretic and non-paretic arms in adults with a prior unilateral stroke and hemiparesis. Researchers will compare radiographic measurements from routine shoulder X-rays with systemic DXA bone density values to see if X-ray-based thickness can indicate regional bone loss. Data will come from patients 18 years and older who had a single stroke at least six months ago and have both shoulder radiographs and DXA data available within six months post-stroke. The study aims to determine if standard shoulder imaging could serve as an accessible screening tool for regional osteoporosis risk in the paretic arm.
Why it matters
Potential benefit: If successful, clinicians could use routine shoulder X-rays to screen for regional bone loss after stroke, potentially guiding prevention of fractures.
How similar studies have gone: Prior work supports the idea that imaging-based bone measurements can reflect bone health, but this specific shoulder radiograph–DXA correlation after stroke is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years and older. * A documented history of a single unilateral stroke that occurred at least 6 months prior to evaluation. * Presence of clinical hemiparesis. * Availability of concurrent standard anteroposterior (AP) shoulder radiographs taken within 6 months post-stroke alongside systemic DXA measurements. Exclusion Criteria: * History of surgical intervention in either shoulder. History of a proximal humerus fracture. * Co-existing metabolic bone diseases, such as primary hyperparathyroidism or osteomalacia. * History of malignancy. * Documented history of corticosteroid use. * Imaging artifacts that compromise the accuracy of DXA measurements. * History of a secondary stroke.
Where it's running
-
Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Ismet Alkim Ozkan MD
- Email: dr.alkimozkan@gmail.com
- Phone: +905356350591
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.