How high blood pressure may weaken bones and affect healing
BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to Bone (FRACTURE CURB): Role of Hypertension in Favoring Osteoporosis
Researchers are working to help aging Veterans with high blood pressure keep bones stronger and heal fractures faster by boosting how parathyroid hormone builds bone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11212764 on NIH RePORTER |
What this research studies
If you are an aging Veteran with bone loss or a fracture, this project looks at how common health problems like hypertension make bones weaker and slow recovery. The team uses lab models that mimic diseases that weaken bone or delay repair to test ways to make parathyroid hormone (PTH) better at building bone. They will measure disease and treatment effects on bone in the same rigorous way and search for safer detection tools and therapies that avoid rare side effects of current drugs. Most work is currently in preclinical models, with the goal of translating findings into better prevention and healing for people like you.
Who could benefit from this research
Good fit: Ideal candidates would be older adults—especially Veterans—who have osteoporosis, a history of fragility fractures, or hypertension that may affect bone health.
Not a fit: People without bone loss, fracture risk, or bone problems caused by unrelated conditions are unlikely to see direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent osteoporosis and speed fracture healing with fewer side effects for Veterans and older adults.
How similar studies have performed: Anabolic therapy with PTH already helps build bone, but enhancing PTH by targeting hypertension-related pathways is a newer approach with limited clinical testing so far.
Where this research is happening
Nashville, United States
- Veterans Health Administration — Nashville, United States (Active)
Researchers
- Principal investigator: Nyman, Jeffry Stephen — Veterans Health Administration
- Study coordinator: Nyman, Jeffry Stephen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.