Analyzing metabolic profiles of blood stem cells in older adults with clonal hematopoiesis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study involves collecting blood and bone marrow samples from patients aged 65 and older who are undergoing hip arthroplasty surgery. The samples will be analyzed for metabolic profiling and to identify mutations associated with clonal hematopoiesis of indeterminate potential (CHIP). Researchers will utilize advanced techniques such as single-cell transcriptomics and mutation-specific genotyping to compare gene expression profiles of normal and mutant hematopoietic stem cells, focusing on metabolic pathways. The goal is to better understand the relationship between aging, metabolic changes, and clonal hematopoiesis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 65 years and older

Exclusion Criteria:

* known haematological condition (myelodysplasia, leukemia, cancer)
* inability to provide written informed consent

Where it's running

• Imelda Hospital
  Bonheiden, België, Belgium Recruiting

Study contacts

• Principal investigator: Nick Van Gastel, PhD — de Duve Institute
• Study coordinator: Michaël R. Laurent, MD PhD
• Email: michael.laurent@imelda.be
• Phone: +32485143267

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.