China health screening using low-dose chest CT to measure spine bone density and body/liver fat
China Nationwide Multi Center Big Data Study on the Quantitative Computed Tomography (QCT) and Health Status of Check -up Population
This project uses low-dose chest CT scans and QCT to test whether spine bone density, visceral fat, and liver fat can be measured in adults getting routine health checks across China.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30000 (estimated) |
| Ages | 30 Years to 90 Years |
| Sex | All |
| Sponsor | Beijing Jishuitan Hospital Academic / other |
| Locations | 6 sites (Wuhu, Anhui and 5 other locations) |
| Trial ID | NCT03699228 on ClinicalTrials.gov |
What this trial studies
This nationwide, multi-center observational project collects low-dose chest CT raw data from health-check participants aged 30–90 at several Chinese hospitals. Investigators apply quantitative CT (QCT) processing to derive spinal bone mineral density, visceral adipose tissue volume, and liver fat content from existing CT data without additional scans. Pregnant women and people with metal implants in the scan area are excluded. The study will report how well QCT performs in the health-check setting and estimate the prevalence of osteoporosis, obesity, and liver steatosis in the screened population.
Who should consider this trial
Good fit: Adults aged 30–90 undergoing low-dose chest CT for routine health checks at participating Chinese centers who are not pregnant and have no metal implants in the scan area.
Not a fit: People outside the 30–90 age range, pregnant women, or those with metal implants in the chest/scan area may not receive useful QCT measurements from this protocol.
Why it matters
Potential benefit: If successful, routine low-dose chest CTs could also identify people with low bone density, excess visceral fat, or fatty liver so they can receive earlier follow-up and care.
How similar studies have performed: Previous opportunistic QCT analyses of routine CT scans have shown feasibility for measuring bone density, visceral fat, and liver fat in other cohorts, though large nationwide multi-center validation across China is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: health check subjects 30-90 years old low dose chest CT scan Exclusion Criteria: pregnant women metal implant in the CT scan area
Where this trial is running
Wuhu, Anhui and 5 other locations
- Wu Hu Yijishan Hospital — Wuhu, Anhui, China (Recruiting)
- Beijing Jishuitan hospital — Beijing, Beijing Municipality, China (Recruiting)
- The first affiliated hospital of Guiyang Medical University — Guiyang, Guizhou, China (Recruiting)
- The first affiliated hospital of Zhengzhou University — Zhengzhou, Henan, China (Recruiting)
- Hua Shan hospital — Shanghai, Shanghai Municipality, China (Recruiting)
- Shanghai Ruijin hospital — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Principal investigator: xiaoguang cheng, MD — Beijing Jishuitan Hospital
- Study coordinator: xiaoguang cheng, md
- Email: xiao65@263.net
- Phone: 0086-010-58516947
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.