Trans-omics approach to understand osteoporosis risk in people
Official title: Trans-omics Integration of Multi-omics Studies for Osteoporosis
Funded at Tulane University of Louisiana · NIH-11365772 · Data updated 2026-11-12
A large-scale human study to uncover how genes, the gut microbiome, and their interactions affect bone density and fracture risk in diverse groups.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | September 15, 2017 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $2,105,754 |
| NIH project number | 5U19AG055373-10 |
| Project ID | NIH-11365772 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults at risk for osteoporosis or with low bone density, including diverse sex and ethnic groups.
✕Less likely to help
Individuals without bone density concerns or those not represented in the study populations may see limited direct benefit.
What this research studies
This project aims to identify how human genes and gut bacteria influence bone health and fracture risk in people. Researchers will study human genomes, gut microbiomes, epigenetic marks, and cell interactions in bone-forming and bone-resorbing cells to understand osteoporosis better. The effort builds on prior work and creates a comprehensive framework to link biology from genes to how bones become fragile. Findings could reveal new targets for preventing osteoporosis and fractures in patients.
Why it matters
Potential benefit: People at risk for osteoporosis could receive earlier, more personalized strategies to protect bone health.
How similar studies have gone: Previous studies show that integrating human genetics and microbiome data can reveal important factors for complex diseases like osteoporosis.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Deng, Hong-Wen — Tulane University of Louisiana
- Study coordinator: Deng, Hong-Wen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.