MicroRNA and bone markers linked to response to romosozumab and abaloparatide in postmenopausal osteoporosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study is an interventional, biomarker-driven investigation in postmenopausal women with osteoporosis. It will analyze microRNA profiles and bone metabolism markers to see if they correlate with treatment response to romosozumab and abaloparatide. Participants will be women with osteoporosis who are already candidates for anabolic or antiresorptive therapies, and the study will compare biomarker patterns with outcomes related to bone formation and resorption. The approach aims to identify signals that might guide personalized therapy by matching patients to the most effective treatment based on their molecular markers. The trial is conducted at two Lombardy centers in Italy under the lead sponsorship of Istituto Auxologico Italiano.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female sex
* Postmenopause
* Densitometric diagnosis of osteoporosis
* Normal calcium diet
* Supplement with cholecalciferol or calcifediol

Exclusion Criteria:

* Premenopause
* Chronic therapy with glucocorticosteroids, or other treatments that may affect bone metabolism
* Diseases and conditions that may affect bone metabolism

Where it's running

• Istituto Auxologico Italiano IRCCS
  Miano, Lombardy, Italy Recruiting
• IRCCS Ospedale Galeazzi Sant'Ambrogio
  Milan, Lombardy, Italy Not yet recruiting

Study contacts

• Study coordinator: Sabrina Corbetta, Prof.
• Email: s.corbetta@auxologico.it
• Phone: +3902619111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.