Blocking RANKL with denosumab to protect ovarian follicles

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will give participants either denosumab or a placebo (PBS) and monitor ovarian follicle development during treatment. Outcomes will be tracked using hormone measurements, ultrasound assessments of follicle counts, and assisted reproduction cycle results where applicable. The protocol targets mechanisms of RANKL signaling that preclinical work suggests influence early folliculogenesis. The aim is to determine whether RANKL inhibition can reduce the impact of ovarian aging on fertility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female in the age of 18 or above, Normal AMH-value, able to give concent

Exclusion Criteria:

* Patients who have had autotransplanted ovarian tissue

Where it's running

• Regionshospitalet, Skive, Midt Jylland 7800
  Skive, Midt Jylland, Denmark Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.