Investigating new therapies to improve bone health in older adults
Center of Research Translation on Osteoporosis Bone Anabolic Therapies
This study is looking at ways to improve treatments for osteoporosis, a condition that affects many older adults by weakening bones, and it aims to find out why some current therapies stop working over time, so we can develop better options for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11085953 on NIH RePORTER |
What this research studies
This research focuses on osteoporosis, a significant health issue for the aging population, and aims to enhance current treatments that help build bone density. It explores the mechanisms behind existing bone anabolic therapies, such as parathyroid hormone receptor agonists and anti-sclerostin antibodies, to understand why their effectiveness diminishes over time. By collaborating with a network of international experts, the project seeks to translate scientific knowledge into better treatment options for osteoporosis. Patients may be involved in studies that assess the impact of these therapies on bone health.
Who could benefit from this research
Good fit: Ideal candidates for participation are older adults diagnosed with osteoporosis who are at high risk for fractures.
Not a fit: Patients with osteoporosis who are not responsive to current anabolic therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments that significantly reduce fracture risks in older adults.
How similar studies have performed: Previous research has shown promise in using anabolic therapies for osteoporosis, but this project aims to address gaps in understanding their long-term efficacy.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wein, Marc Nathan — Massachusetts General Hospital
- Study coordinator: Wein, Marc Nathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.