Investigating new therapies to improve bone health in older adults
Official title: Center of Research Translation on Osteoporosis Bone Anabolic Therapies
Funded at Massachusetts General Hospital · NIH-11085953 · Data updated 2026-11-12
This study is looking at ways to improve treatments for osteoporosis, a condition that affects many older adults by weakening bones, and it aims to find out why some current therapies stop working over time, so we can develop better options for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,392,115 |
| NIH project number | 5P50AR080596-03 |
| Project ID | NIH-11085953 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are older adults diagnosed with osteoporosis who are at high risk for fractures.
✕Less likely to help
Patients with osteoporosis who are not responsive to current anabolic therapies may not benefit from this research.
What this research studies
This research focuses on osteoporosis, a significant health issue for the aging population, and aims to enhance current treatments that help build bone density. It explores the mechanisms behind existing bone anabolic therapies, such as parathyroid hormone receptor agonists and anti-sclerostin antibodies, to understand why their effectiveness diminishes over time. By collaborating with a network of international experts, the project seeks to translate scientific knowledge into better treatment options for osteoporosis. Patients may be involved in studies that assess the impact of these therapies on bone health.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments that significantly reduce fracture risks in older adults.
How similar studies have gone: Previous research has shown promise in using anabolic therapies for osteoporosis, but this project aims to address gaps in understanding their long-term efficacy.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Wein, Marc Nathan — Massachusetts General Hospital
- Study coordinator: Wein, Marc Nathan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.