Using an osteoporosis medication to help older adults maintain muscle health
Official title: Preserving Geriatric Muscle with an Osteoporosis Medication
Funded at University of Pittsburgh at Pittsburgh · NIH-11087486 · Data updated 2026-11-12
This study is looking at whether Denosumab, a medication for osteoporosis, can help older adults keep their muscles strong and stay active, which may lower their chances of falling or getting hurt.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $652,778 |
| NIH project number | 5R01AG081359-03 |
| Project ID | NIH-11087486 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 65 and older who are at risk for falls and have low muscle mass or function.
✕Less likely to help
Patients under the age of 65 or those without issues related to muscle health or osteoporosis may not benefit from this research.
What this research studies
This research investigates the effects of Denosumab, a medication typically used for osteoporosis, on muscle health in older adults. The study aims to determine if this medication can help preserve muscle strength and mobility, thereby reducing the risk of falls and fractures in seniors. By focusing on the relationship between muscle and bone health, the research seeks to address the dual challenges of osteoporosis and sarcopenia in the elderly population. Participants will be monitored for improvements in their physical function and overall quality of life.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of falls and fractures among older adults, improving their quality of life.
How similar studies have gone: Previous studies have shown promising results with Denosumab in reducing falls and fractures, indicating that this approach may be effective.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Greenspan, Susan L — University of Pittsburgh at Pittsburgh
- Study coordinator: Greenspan, Susan L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.