Self‑questionnaire to spot rare genetic bone conditions in adults with osteoporosis
Clinical Validation of a Self-questionnaire in Adults With Osteoporosis
This project tests whether a self‑administered questionnaire can help identify rare genetic bone diseases in adults with osteoporosis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 58 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | CHU de Quebec-Universite Laval Academic / other |
| Drugs / interventions | prednisone |
| Locations | 1 site (Québec, Quebec) |
| Trial ID | NCT07067827 on ClinicalTrials.gov |
What this trial studies
Researchers will compare answers from a self‑administered questionnaire to information collected by telephone using a family tree to test the questionnaire's validity. Participants are adults with osteoporosis followed at CHU de Québec–Université Laval and will be randomized to complete either the questionnaire or the family‑tree interview first, with the other method repeated three months later. Clinical and sociodemographic data will be extracted from electronic medical records to describe participants and disease severity. The goal is to see how well the questionnaire matches the family‑tree information and to adapt it to improve accuracy for clinical screening.
Who should consider this trial
Good fit: Adults (age ≥18) with osteoporosis who are followed in the rheumatology or endocrinology clinics at CHU de Québec–Université Laval and who have internet access are the intended participants.
Not a fit: People who cannot consent or complete questionnaires, those with unknown family history (for example, adopted persons), or those without internet access are unlikely to benefit from this approach.
Why it matters
Potential benefit: If successful, the questionnaire could make it easier to detect rare genetic bone diseases earlier and enable more personalized care for people with osteoporosis.
How similar studies have performed: Self‑reported family‑history questionnaires have been used in other genetic risk screenings with mixed accuracy, and this specific questionnaire is newly developed by the team and has not yet been validated.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult over 18 * Followed by the rheumatology or endocrinology clinics at the CHUL (CHU de Quebec-Universite Laval) * Suffer from osteoporosis * Have internet access Exclusion Criteria: * Unfit, unable to consent, unable to answer a questionnaire, unknown family history (e.g. adopted person)
Where this trial is running
Québec, Quebec
- CHU de Quebec-Universite Laval — Québec, Quebec, Canada (Recruiting)
Study contacts
- Principal investigator: Laetitia Michou, MD PhD — CHU de Quebec-Universite Laval
- Study coordinator: Laetitia Michou, MD PhD
- Email: laetitia.michou@crchudequebec.ulaval.ca
- Phone: +14185254444
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.